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Mechanism-based inactivation of CYP3A by HIV protease inhibitors.
With the accumulation of post-marketing data concerning concomitant administration of INVIRASE(R) and other drugs, it was found that concomitant use with HIV protease inhibitor ritonavir (product name: NORVIR(R))caused significant increase of blood INVIRASE(R) concentration.
High-performance liquid chromatographic determination of a potent and selective HIV protease inhibitor (L-735,524) in rat, dog and monkey plasma.
There are numerous examples of marketed drugs that achieve a therapeutic effect by inhibiting protease activity, including HIV protease inhibitors for the treatment of HIV and AIDS, and angiotensin converting enzyme inhibitors for the treatment of hypertension.
Eliminating the need for ritonavir, which is currently co-administered per label with all once-daily HIV protease inhibitors to increase their blood levels, could provide significant advantages over current standard-of-care.
ACT6 A5146 is a study that will examine the effect of adjusting the dose of a patient's HIV protease inhibitor (PI) on controlling HIV viral load levels.
Vertex co-discovered the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.
The company added that Tybost is indicated as a boosting agent for the HIV protease inhibitors atazanavir 300 mg once daily and darunavir 800 mg once daily as part of antiretroviral combination therapy in adults with HIV-1 infection.
The product is used with other medications to control HIV infection and is included in the ARV class of drugs known as HIV protease inhibitors.