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Related to HLA complex: HLA system, Human lymphocyte antigen
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These HLA complexes helps body's immune system to recognize its own proteins from proteins made by foreign invaders such as viruses and bacteria's31.
Functional trimeric affinity-purified HLA complexes were analyzed for the presence of CBZ or EPX via mass spectrometry.
In order to analyze the peptidome of B*15:02, the human lymphoblastoid cell line LCL721.221 was transduced with lentiviral vectors encoding for sB*15:02 and functional HLA complexes were purified via affinity purification.
Further, disease-related HLA complexes can be targeted by specific antibodies that facilitate the development of vaccine and therapeutic solutions.
Recognition of non-self peptides in HLA complexes is indicative of disease status and prompts the action of CD8+ T-lymphocytes (CTLs), which control or eliminate diseased cells by release of cytotoxic molecules and cytokines to further mobilize the immune system to the particular site of discovery.