Laboratory experiments have shown that supporting cells from mice can be coaxed into becoming hair cells
in part by blocking production of p27.
Animal experiments have shown that hair cells
sensitive to high end frequencies are more vulnerable to noise damage.
Distortion-product otoacoustic emissions (DPOAE) are the sounds emitted by the outer hair cells
of the cochlea in response to a pair of simultaneously presented pure-tone stimuli.
The damage caused by noise -- over a lifetime or just one evening -- reduces the ability of hair cells
to talk to the brain via ribbon synapse connections with nerve cells.
Whereas previous research indicated that hair cells
are not replaced, this latest study found that replacement does indeed occur, but at very low levels.
This is an area that's a bit more futuristic and ultimately restoring the hair cells
will be the cure.
When it's moving at the same speed as you, the hair cells
no longer send a signal to the brain.
The bulk of the damage caused by loud noises is done at the level of the hair cells
Together with her colleagues, she also unraveled the roles of most of the proteins encoded by these genes, namely in the sensory hair cells
, their stimulating gel, and the supporting cells, by multidisciplinary studies of engineered mouse models.
However, the number of inner hair cells
which transmit amplified sound signals to the brain, appeared normal.
Humans are born with 30,000 hair cells
in each ear.
Free-radical species are produced by NADPH oxidase in the inner hair cells
following cisplatin exposure.