The ridge consists of six rows of
hair cells. All
hair cells of a row are morphologically similar to each other, but the rows are not identical.
Combining this new knowledge about Lgr5-expressing cells with the previous finding that Notch inhibition can regenerate
hair cells will allow the scientists to design new
hair cell regeneration strategies to treat hearing loss and deafness.
Abortive synaptogenesis as a factor in the inner
hair cell degeneration in the Bronx Waltzer (bv) mutant mouse.
"After covering the
hair cell with a synthetic cupula, our bio-inspired microsensor had the ability to detect flow better than the blind fish," Tsukruk said.
NF-kappaB pathway protects cochlear
hair cells from aminoglycoside-induced ototoxicity.
Most cochlear
hair cells have multiple auditory nerve fibers attached to them, and there is evidence for differences in the size of the synaptic endings of these neurons.
For years, scientists worldwide have been searching for ways to regenerate functioning
hair cells. The UM team credits its success to the advances made by others in gene delivery systems and in understanding the molecular mechanism that controls
hair cell development.
Potentiation of noise induced threshold shifts and
hair cell loss by carbon monoxide.
Finally, each
hair cell sends a message to the brain that indicates the sound that you hear.
And intense sound waves from hazardous noise levels can destroy
hair cells in the inner ear (see p.
New
hair cells form in the papilla, pushing up old cells.
Deafness may be caused by damaged or destroyed
hair cells inside the ear.