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A number of studies suggest that ERC's contribute to the formation of Hassall's corpuscles14, therefore any effect on ERC'S might affect Hassall's corpuscles. To investigate this possibility, the number and length of Hassall's corpuscles was also determined.
Hassall's corpuscles were identified by their characteristic swirly appearance.
Similarly the diameter of Hassall's corpuscles was measured along its long axis through 100x objective in three randomly selected different fields.
Tg-positive Hassall's corpuscles were not found (Supplemental Table 1), while Tg staining was observed in thymocytes in this single sample (1/22, 4.5%; Supplemental Table 2 and Figure 4(c)).
Unlike other NIS-positive cases, Hassall's corpuscles stained with the cytokeratin antibody or NIS antibody were not detected in the thymic tissue (Figure 5(c) and (d)).
NIS, TSHR, and TPO were distinctively localized to Hassall's corpuscles. This result is in agreement with the study of Vermiglio et al.
Good number of relatively large Hassall's corpuscles, branching blood vessels at cotico-medullary junction and thicker capsule with wider inter lobular septae were observed in the present study in thymic glands of 20-24 weeks old fetuses.
Liberti et al (1994) reported that the mean areas of the Hassall's Corpuscles increased with the foetal age, with the greatest observable difference between 16th to 19th and 20th to 23rd weeks.
(12.) Liberti EA, Fagundes T P, Perito M A, Matson E, Konig Junior B: On the size of Hassall's corpuscles in human fetuses.
Medulla exhibited a number of Hassall's corpuscles which varied in size and shape.
Thymus in the age group of 11-20 exhibited normally lobulated thymus with Hassall's corpuscles in the medulla.