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In the hours following maximum MDMA concentrations, S/P ratios decreased and reached almost constant values (~7), but were still higher than the theoretical value from the Henderson-Hasselbalch equation.
The percentage of free (unprotonated) nicotine, which is dependent on the pH, was calculated according to the Henderson-Hasselbalch equation and by using a [pK.
Equilibrium constants, the Henderson-Hasselbalch equation, dose-response curves 23.