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Related to Humanized antibodies: Chimeric Antibody
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Antitope provides immunogenicity assessment, protein engineering to create humanized antibodies and deimmunised therapeutic proteins, and cell line development for manufacture.
The license was granted under the terms of an agreement announced by the two companies in January 2000 covering certain intellectual property in the field of humanized antibodies, and triggers payment of an additional license fee to Protein Design.
The company is in preclinical development of humanized antibodies to P-selectin and PSGL-1 for the treatment of acute and chronic inflammatory and thrombotic disorders.
Forty additional humanized antibodies are in clinical trials.
Nanoviricides creation does not require humanized antibodies, nor does it require monoclonal antibodies development.
We have developed a number of advanced proprietary technologies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents.
Protein Design has granted licenses under its antibody humanization patents for each of the three currently marketed humanized antibodies.
This enables us to offer state of the art support to pharmaceutical and drug development companies as we seek to increase antibody potency, an achievement already demonstrated with other multiple fully human and humanized antibodies.
Several of the humanized antibodies produced to date retain the desired binding characteristics.
Overall, Protein Design has entered into agreements with numerous pharmaceutical and biotechnology companies for exclusive or non-exclusive rights under its antibody humanization patents covering more than 40 humanized antibodies, over half of which are in clinical development.
For human medicine, cloning may be used to develop animals that secrete therapeutic proteins in their milk, that produce humanized antibodies for use as vaccines or that produce animal tissues modified for xenotransplantation.