Recent evidence described the unique pathological features of Hurthle cell
carcinoma, different oncogenesis and clinical characteristics as compared to papillary and follicular carcinoma of the thyroid gland.
Some details were incomplete and information regarding subsequent management for Hurthle cell
carcinoma in term of completion thyroidectomy and RAI ablation therapy were not looked into.
Besic, "Expression of miRNA and occurrence of distant metastases in patients with Hurthle cell
carcinoma," International Journal of Endocrinology, vol.
Correlation between the Expression of Autophagy-Related Proteins and Clinicopathologic Factors in Hurthle Cell
Carcinomas and Follicular Carcinomas.
carcinoma: a population-level analysis of 3311 patients.
We initially attributed the pancytokeratin immunoreactivity to nonspecific uptake by nonviable malignant cells; however, in retrospect this was due to entrapped Hurthle cells
within the neoplasm.
(2015) MEN1 mutations in Hurthle cell
(oncocytic) thyroid carcinoma.
FNA Frozen Final section pathology Negative Negative 19 Benign Positive 1 FVPC Positive Negative 12 Positive 2 FVPC x2 Negative Negative 19 Follicular ca AUS/FLUS Positive 1 Positive Negative 10 Positive 3 Follicular ca, FVPC, micropapillary ca Negative Negative 14 Micropapillary ca FN/SFN Positive 1 Positive Negative 6 Positive 5 Papillary ca, micropapillary ca x2, FVPC, Hurthle cell
ca Negative Negative SM Positive 1 0 Positive Negative 1 0 Positive AUS/FLUS: atypia/follicular lesion of undetermined significance; FN/SFN: follicular neoplasm or suspicious for follicular neoplasm; SM: suspicious for malignancy; FNA: fine needle aspiration biopsy; FVPC: follicular variant of papillary carcinoma; ca: carcinoma.
Fine-needle aspiration biopsy of Hurthle cell
lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis.
* Follicular neoplasm or suspicious for follicular neoplasm, including nonpapillary follicular-patterned lesions/neoplasms and Hurthle cell
Final pathology of the thyroid gland showed follicular carcinoma with Hurthle cell
features [Figure 5].
Selenoprotein expression in Hurthle cell
carcinomas and in the human Hurthle cell
carcinoma line xtc.Ucl.