carcinoma is a better gold standard than Hurthle cell
neoplasm for thyroid fine-needle aspirates: defining more consistent and specific cytologic criteria.
Histiocytes with hemosiderin favor a benign diagnosis (if papillary thyroid carcinoma and Hurthle cell
neoplasms are excluded).
carcinoma: a critical histopathologic appraisal.
At our institution, the "suspicious" category was usually followed by a descriptive diagnosis of "suspicious for follicular neoplasms," "suspicious for Hurthle cell
neoplasms," or "suspicious for papillary carcinoma.
of Cases Hyperplastic nodule 1 Goiter 4 Adenoma 3 Hurthle cell
adenoma 5 PTC, usual 14 PTC, solid 2 PTC, Warthin-like 1 PTC, follicular variant 15 PTC, tall cell 5 PTC, columnar 1 PTC, diffuse sclerosing 2 PTC, microcarcinoma 2 Metastatic PTC 3 Follicular thyroid carcinoma 3 Hurthle cell
carcinoma 8 Poorly differentiated carcinoma 1 Anaplastic carcinoma 2 Insular carcinoma 2 Medullary thyroid carcinoma 1 * PTC indicates papillary thyroid carcinoma.
Carcinoma Showing Multiple AgNORs (1000x)
Management of thyroid Hurthle cell
neoplasms: A single centre experience and literature review.
2015) MEN1 mutations in Hurthle cell
(oncocytic) thyroid carcinoma.
6 55 Suspicious Suspicious Malignancy FN malignancy (n = 37) (n = 78) (n = 273) NH (n = 182) 13 1 0 Thyroiditis (n = 16) 2 0 0 FA/HA (n = 17) 10 1 0 FTC (n = 25) 9 1 2 MTC (n = 9) 0 1 1 PTC (n = 440) 3 73 270 ATC (n = 1) 0 1 0 Malignant risk (%) 32 97 100 NH: nodular hyperplasia; FA: follicular adenoma; HA: Hurthle cell
adenoma; FTC: follicular thyroid carcinoma; MTC: medullary thyroid carcinoma; PTC: papillary thyroid carcinoma; ATC: anaplastic thyroid carcinoma; AUS: atypia of undetermined significance.
This applies to glands with many different pathologies, including papillary thyroid carcinoma, Hashimoto thyroiditis, Hurthle cell
adenoma, and multinodular goiter.
Malignant oncocytic tumours are rare, but they occur in thyroid as hurthle cell
Atypia of undetermined significance or follicular lesion of undetermined significance where the cytologic findings were not convincingly benign, yet the degree of cellular or architectural atypia was insufficient for an interpretation of follicular neoplasm, Hurthle cell
neoplasm, or suspicious for malignancy.