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In past xenotransplants, surgeons could avoid hyperacute rejection by using organs from chimpanzees, the primate genetically most like humans.
The development of [alpha]1,3Gal deficient pigs expressing human complement regulatory proteins such as hDAF, MCP, and CD59 is necessary to overcome hyperacute rejection of pig organs transplanted into non-human primates by gene targeting technology.
1999) and has been used precisely to remove donor specific antibodies that would cause hyperacute rejection or acute antibody-mediated rejection (Montgomery et al.
Four healthy piglets are born without the gene--alpha 1, 3 galactose- responsible for making an enzyme that adds sugar to the surface of pig cells that leads to hyperacute rejection of the pig organ.
2008) observed that no hyperacute rejection developed and one graft survived up to 6 months after transplantation.
Because both copies of the gene have been inactivated, tissues from these pigs have been shown to be completely devoid of the pig sugar that cause the pig sugar that caused the hyperacute rejection to take place.
Prevention of hyperacute rejection by removal of antibodies to HLA immediately before renal transplantation.
The rejection of donor organs is a barrier even in human-to-human transplantation, one addressed by immunosuppressive drugs such as cyclosporine; hyperacute rejection, in which donor organs are rapidly destroyed, poses an even greater barrier in animal-to-human transplants.
The product is currently in preclinical development at Nextran for the treatment of hyperacute rejection associated with xenotransplantation, a procedure involving the transplant of animal organs into human recipients.
No hyperacute rejection occurred, and the incidence of acute rejections did not differ based on whether a pretransplant crossmatch was performed or not.