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Related to Hyperbilirubinaemia: hyperbilirubinemia
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JAUNDICE, OR hyperbilirubinaemia, is a symptom arising in a number of diseases.
We searched the electronic database of Medline for publications containing the terms 'drug-induced hyperbilirubinaemia' in combination with 'pregnancy' and found no reports providing evidence that maternal hyperbilirubinaemia during organogenesis could result in organic abnormalities in a surviving infant.
Any infant with factors increasing the likelihood of hyperbilirubinaemia (see Box 2) should receive a visual inspection for jaundice by a health professional in the first 48 hours of life.
Differentiation between hyperbilirubinaemias (4) Unconjugated Split bilirubin test Conjugated bilirubin less than 20% of total bilirubin Urine colour Colourless Stool colour Yellow, brown, green Cause Can be physiological or pathological Implications High levels can cause brain damage (kernicterus)--refer to paediatrician if total bilirubin is greater than 200micromol/l Conjugated Split bilirubin test Conjugated bilirubin greater than 20% of total bilirubin Urine colour Yellow Stool colour Pale lemon, white, grey Cause Always pathological and indicates liver disease Implications Requires prompt referral to a paediatrician
Molecular diagnosis of a familial nonhemolytic hyperbilirubinaemia (Gilbert's syndrome) in healthy subjects.
Cases requiring hospital care for hyperbilirubinaemia were included as non-urgent because the clinical signs were not intended to identify jaundiced babies.
Accuracy in interpreting and acting upon findings is paramount in the prevention of hyperbilirubinaemia and subsequent morbidity.
However, predominantly conjugated hyperbilirubinaemia has been reported in P.
Lastly, a study comparing boosted and unboosted atazanavir with extended release stavudine and lamivudine showed less virological failure and the absence of phenotypic resistance in those taking boosted drug at 96 weeks but with greater rates of hyperbilirubinaemia and increases in lipid levels, reflecting the effect of low-dose ritonavir [40].
Isolated unconjugated hyperbilirubinaemia (drug-induced Gilbert's syndrome) is associated with certain PIs (IDV and especially ATV).
It is useful to remember that atazanavir causes an unconjugated hyperbilirubinaemia through an acquired 'Gilbert's syndrome'-like mechanism.