Inagi et al., "Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor
in the kidney," Kidney International, vol.
These adaptive responses are orchestrated by the hypoxia-inducible factors
(HIFs), "master" regulators of the hypoxic response .
Gatter et al., "The expression and distribution of the hypoxia-inducible factors
HIF-1[alpha] and HIF-2[alpha] in normal human tissues, cancers, and tumor-associated macrophages," The American Journal of Pathology, vol.
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor
induction of BNIP3 and BNIP3L via their BH3 domains.
1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Bunn, "Regulation of hypoxia-inducible factor
1alpha is mediated by an [O.sub.2]-dependent degradation domain via the ubiquitin-proteasome pathway," Proceedings of the National Academy of Sciences of the United States of America, vol.
Semenza, "HER2 (neu) signaling increases the rate of hypoxia-inducible factor
1a (HIF-1a) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression," Molecular & Cellular Biology, vol.
Various stimuli, such as ROS and CI [7, 8], are able to activate hypoxia-inducible factor
Kretschmer et al., "Hypoxia-inducible factor
1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formation," Infection and Immunity, vol.
And rather than esophagitis due to GERD being a top-down process, from surface epithelium to submucosa, multiple lines of evidence now suggest it is a bottom-up phenomenon sparked by activation of a hypoxia-inducible factor
that occurs when esophageal epithelium is exposed to acidic bile salts, Rhonda Souza, MD, said at the meeting sponsored by the American Gastroenterological Association.
Based on target prediction programs (miRTarBase, TargetScan, miRanda, and MiRBase) and published papers, we found highly evidenced candidate target genes (hypoxia-inducible factor
1A and Cullin 2 genes for hypoxia and angiogenesis; cyclin-dependent kinase 6 (CDK6), Cyclin D1 (CCND1), Cyclin E1 (CCNE1), and CCND3 genes for cell cycle) of hsa-miR-424-5p.
IGF-1 induces hypoxia-inducible factor
1a-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells.