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The most common high-grade irAEs in this group were elevated lipase, diarrhea, and transaminitis, occurring in 38%, 25%, and 25% of patients, respectively.
The use of systemic steroids to manage irAEs was similar in the Ipi and anti-PD-1 monotherapy groups (28% in both groups), but 75% of the combination therapy patients were treated with systemic steroids.
He cited a recent systematic review and meta-analysis showing that among patients treated with any anti-CTLA-4, the overall incidence of all-grade irAEs was 72%, and the overall incidence of high-grade irAEs was 24%.