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These include Bcl2, CCND1, CXCL1, CXCL3, IL-18, IL-6, IRF1, NF-KB1, PTGS2, TNF-[alpha], TNFSF10, TRADD, and TRAF1.
Validation of the microarray study by real time analysis showed that mRNA expression ofTNF-a, IL-6, NF-KB1, and IRF1 (all of which are downstream targets of NF-KB binding) was significantly inhibited in presence of chlorojanerin (Fig.