Pit

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PIT, fossa. A hole dug in the earth, which was filled with water, and in which women thieves were drowned, instead of being hung. The punishment of the pit was formerly common in Scotland.

References in periodicals archive ?

SNPs and interaction analyses of IRF6, MSX1 and PAX9 genes in patients with non-syndromic cleft lip with or without palate.

Interaction Effect of Rsal and BamHI Polymorphisms of TGF[alpha], BMP2 and BMP4 on the Occurrence of Non-Syndromic Cleft Lip and Palate in Iranian Patients

The results of this study suggest that IRF6 is the main factor expressed in connective tissues of the oral mucosa, and the downregulation of IRF6 in the oral epithelium of CBCLP cases indicates that it may be responsible for a decrease in the differentiation potential of epitheliocytes in CLP.

IRF6, RYK, and PAX9 Expression in Facial Tissue of Children with Cleft Palate/ Expresion de IRF6, RYK y PAX9 en el Tejido Facial de Ninos con Paladar Fisurado

"As it has been shown for IRF6, one or several polymorphisms in GRHL3 might be found to be associated with increased risk of clefts in non-syndromic cases," Peyrard-Janvid added.

New gene linked to cleft lip and palate syndrome identified

Malhotra et al., "Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch," Nature Genetics, vol.

Delineating molecular mechanisms of squamous tissue homeostasis and neoplasia: focus on p63

Kondo et al., "Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)," Nature Genetics, vol.

Interferon-regulatory factors determine macrophage phenotype polarization

Viseletal., "Disruptionofan AP-2[alpha] binding site in an IRF6 enhancer is associated with cleft lip," Nature Genetics, vol.