The database also includes pharmaceutical companies, biotech companies, CROs, hospitals, government labs and other organisations active in the Integral Membrane Protein
12 Solubilization, Purification, and Characterization of Integral Membrane Proteins
Specialized integral membrane proteins
known as transporters are responsible for the movement of virtually any known class of biologically active molecules across membranes.
NASDAQ:AFFX) today launched its Anatrace[R] brand Neopentyl Glycol (NG) Class[TM] Detergents, the next generation of detergents to significantly advance the study of integral membrane proteins
(IMPs), the most important proteins found in the human genome.
Integral Molecular is a biotechnology company committed to providing innovative solutions for scientific research and drug discovery applications involving integral membrane proteins
Integral membrane proteins
, such as G protein-coupled receptors (GPCRs) and ion channels, comprise about a third of existing drug targets, and Lipoparticles provide a means of isolating and characterizing antibodies and drugs against these proteins.
Next, the researchers hope the substrate will allow integral membrane proteins
to remain as intact and functional in experimental systems as they are in living cells.
The company's core technology, the lipoparticle, simplifies the discovery of drugs against integral membrane proteins
, a family of biological molecules that comprise greater than 50% of existing drug targets.
The type of proteins we're dealing with, known as transmembrane or integral membrane proteins
, are involved in an enormous array of cell activities, but there hasn't been a good way to isolate and purify them so their individual roles could be studied," says Joseph Sodroski, MD, the study's senior author and director for the Center for AIDS Research at Dana-Farber.