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New class of HIV integrase inhibitors that block viral replication in cell culture.
An investigational integrase inhibitor that could be used in once-daily dosing might overcome that disadvantage, and the agent, S/GSK1349572, has showed promise in a preliminary trial in previously untreated patients with HIV Dr.
Among 8 people in whom SWITCHMRK investigators looked for resistance mutations after Isentress failed, 7 had mutations that make HIV resistant to Isentress and other integrase inhibitors.
For patients with extensive resistance to existing medications, the FDA approval of the well-tolerated and effective integrase inhibitor, raltegravir, was a welcome event.
An earlier integrase inhibitor, S-1360, developed by Shionogi & Co.
Shionogi's S-1360 and Merck's integrase inhibitor in early development).
In the new relationship, Shionogi will receive a royalty on net sales of the integrase inhibitor portfolio averaging in the high teens.
Elvitegravir (EVG, GS-9137, also known as JTK303/GS-9137) is an HIV-1 integrase inhibitor being developed for the treatment of HIV-1 infection.
David Cooper, from the University of New South Wales in Australia, presented early results from a study of the integrase inhibitor raltegravir (Abstracts #105aLB and # 105bLB), formerly known as MK-0518, combined with 3 or more existing HIV drugs (optimized background therapy).
A second integrase inhibitor that is "close on the heels" of MK-0518 in development is GS-9137 (Gilead), Dr.
This integrase inhibitor was synthesized by Shionogi & Co.
The Quad combines Truvada with Elvitegravir (an integrase inhibitor similar to Merck's Isentress) and Cobicistat (a blood booster similar to the decade-old Norvir).