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Caption: Figure 2: Extrinsic and intrinsic pathways of sepsis.
Therapeutic approaches for prevention of lymphocyte apoptosis in murine models of sepsis Strategy Intervention Reference Prevent triggering of Blockade of Fas ligand by using (27) extrinsic pathway Fas fusion protein Prevent triggering of Prevent Fas expression by using (28) extrinsic pathway siRNA Prevent initiation Anti-CD40 agonist antibodies (29) Prevent initiation Treatment with Bcl-2 agonist (30) peptides Prevent triggering of Antiretroviral protease (31) intrinsic pathway inhibitors Prevent execution phase Anticaspase-8 siRNA (28) Prevent execution phase Treatment with caspase (32, 33) inhibitors
After reviewing the deficiencies of the factors of the intrinsic pathway, we still do not have a reasonable explanation for our patient's bleeding.
6,7] When endothelial cells are damaged, the exposed collagen activates FXII, which stimulates the intrinsic pathway and converts prekallikrein to kallikrein to activate fibrinolysis.
This glycoprotein seems to inhibit the activation of the contact phase system of the intrinsic pathway of blood coagulation (10).
Antagonism of Intrinsic Pathway Inhibits Tissue Factor (TF) -- Initiated Coagulation in a Platelet-Dependent Whole Blood Flow Assay" July 11 at 5:30 p.