Cell

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CELL. A small room in a prison. See Dungeon.

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Table--1: Effect of Repetitive Heat Stress (4 hours/day at 37 [+ or -] 0.5[degrees]C) on Numerical density of Kupffer cells on the area (Nak) Experimental Morphometric Controls 02 Days Parameter (n = 6) (n = 6) Nak 4905.7 5046.7 (per [cm.sup.2]) [+ or -]9.47 [+ or -]38.86 ** Experimental Morphometric 05 Days p-value Parameter (n = 6) (ANOVA) Nak 7062 <0.0001 (per [cm.sup.2]) [+ or -]16.89 *** Values are expressed as Mean [+ or -] SEM.
In addition to producing cytokines, activated Kupffer cells are the major source of ROS in the liver, which, in large amounts, can lead to oxidative stress.
de Baetselier et al., "Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells," Nature Communications, vol.
Arrest of Circulating Tumor Cells in the Liver by Binding of CEA to hnRNP M4 in Kupffer Cells and Activation of Kupffer Cells by CEA for Liver Metastasis.
Total RNA was extracted from the liver or LPS treated Kupffer cells using a TRIzol reagent (Invitrogen Corp, Carlsbad, CA, USA) and reversely transcribed into cDNA using reverse transcription kits (Promega, Madison, WI, USA).
The liver typically shows hyperplastic Kupffer cells containing organisms; organism-laden macrophages may form small nodules or loosely formed granulomas (Figure 11).
Experiments in rodent models of ALD have demonstrated that TLR4-TRIF signaling plays an essential role in alcohol-induced activation of TLR4 in Kupffer cells (Hritz et al.
The hepatocytes were arranged in radiating cords proceeding to the peri- phery from the central vein having sinusoids in bet- ween lined by discontinuous endothelial cells with flattened nuclei; among them were kupffer cells withrounded prominent nuclei.
Animals with neoplastic lesions were significantly more likely to co-present with oval cell hyperplasia, hepatocyte hypertrophy, and Kupffer cell hyperplasia, suggesting a proliferative response to perinatal BPA exposure (see Supplemental Material, Tables S5 and S6).
Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials.