(2) Adhesion molecules involved in leukocyteendothelial transduction: L-Selectin
, E-Selectin, ICAM-1, PECAM, and VCAM-1
Although previous studies have described elevations in the levels of individual biomarkers associated with neutrophilic inflammation, specifically ICAM-1 , L-selectin
, and IL-8 , characterization of the effects of cART on a profile ofbiomarkers associated with systemic activation of these cells has not, to our knowledge, been described previously.
is constitutively active, integrins generally need to be activated to mediate adhesion.
A Kruskal-Wallis ranking test was carried out on the Von Frey, and L-selectin
ELISA data and 1-way ANOVA with Bonferroni post hoc tests were used to analyse all other data using GraphPad Prism 4 software (GraphPad software, USA).
The third member of the selectin family is L-selectin
that was actually discovered earlier than the other two selectins  and is expressed on basically all types of leukocytes.
Decreased expression levels of L-selectin
on subsets of leucocytes and increased serum L-selectin
in severe psoriasis.
The shedding of CD62L (L-selectin
) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes.
Further studies will be required before the findings can be translated into direct benefit to patients; however, the team are planning on focusing their efforts at finding ways to reduce the loss of L-selectin
from the surface of killer T cells in order to increase the number of killer T cells that can home in on infected tissues.
Dimitriadis et al., "Subcellular localization of L-selectin
ligand in the endometrium implies a novel function for pinopodes in endometrial receptivity," Reproductive Biology and Endocrinology, vol.
Citation: "Lymphoid priming in human bone marrow begins before expression of CD 10 with upregulation of L-selectin
;" Lisa A.
The lymph node homing receptor, L-selectin
(CD62L), is required for entry of naive lymphocytes into lymph nodes through high endothelial venules.