Parma first showed data from in vitro experiments demonstrating that the Company's L-selectin
oligonucleotide antagonist binds to L-selectin
on the surface of white blood cells such as neutrophils, lymphocytes and monocytes.
The NeXstar Pharmaceuticals' aptamers, however, binds to L-selectin
at least hundreds of times more tightly than do any known small molecules under development, and thus are active at far lower doses.
1- To identify new proteins interacting with L-selectin
tail and identify which one are important for L-selectin
On the other hand, adhesion molecule L-selectin
(CD62L) facilitates adherence of leukocytes to vascular endothelium and subsequent migration of leukocytes between endothelial cells into infected tissue (Perkins et al.
Jensen GS, Hart AN, Zaske LA, et al Mobilization of human CD34+ CD133+ and CD34+ CD133(-) sterm cells in vivo by consumption of an extract from Aphanizomenon flos-aquae-related to modulation of CXCR4 expression by an L-selectin
For instance, CEA, the glycoprotein commonly used as a marker for colorectal cancer (Clinical Tests Based on Cancer-Related Changes in Glycosylation above), and CD44, a highly glycosylated cell-surface adhesion protein, can serve as E- and L-selectin
Antibody to E- and l-selectin
does not prevent lung injury or mortality in septic baboons.
The baby (at this stage referred to as an embryo by scientists) and the lining of the uterus both secrete a protein called L-selectin
The team discovered that the placental cells make L-selectin
, a protein usually seen on white blood cells, such as neutrophils.
University of California (Oakland, CA) has patented a composition to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulindependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroidiris, hemorphagic shock, reperfusion injury during transplantation and multiple sclerosis, which include a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin
In well-conducted experiments, preparations of AFA containing a novel cyanobacterial ligand for human L-selectin
were shown to have an important role in stem cell biology.
A hematopoietic cell L-selectin
ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity.