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We divide the NOAEL or LOAEL by the uncertainty factor.
Considering that experimental animal to human LOAEL ratios are variable over a larger set of chemicals, assessment factors accounting for animal to human differences have been developed as probability distributions.
Compound Lowest 1/1000th Lowest ADE (mg/day) Therapeutic LCD Reported based on LOAEL Dose Teratogenic for Dose Teratogenicity Difenoxin HCL 1 mg 0.
50], LOAEL (low observed adverse effect level), NOEL, NOEC, PEC, PNEC and TDI (tolerance daily intake) described in various Tables are of particular importance.