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En la actualidad, la Red de laboratorios oficiales esta constituida por 28 LOCM pertenecientes a 23 paises de la Region (cuadro 1) y, para su funcionamiento, se utilizan diferentes estrategias, entre las que se describen el sistema virtual ELLUMINATE, la plataforma PRAIS de la OPS y reuniones presenciales.
El estudio de diagnostico de los 28 LOCM mostro que todos ellos cuentan con tecnologia de cromatografia liquida de alta resolucion (HPLC) y equipos para la prueba de disolucion de formas farmaceuticas.
El PCEC realizo, desde 2001 hasta la fecha, ensayos de control externo de desempeno de los 28 LOCM que participan de la Red, divididos en forma secuencial en diez etapas.
In fact, early micropuncture studies in rats found that the IOCM, iotrolan, increased tubular pressure much more and decreased single nephron GFR much more as compared to the HOCM and LOCM studied [53, 54].
Another effect of increased tubular fluid viscosity is that increased flow resistance markedly slows tubular flow [44], so that the intrarenal retention time of IOCM is much longer than that of LOCM, as shown in rats and minipigs [35, 58, 59].
This was demonstrated by a study in rats that compared four solutions: the IOCM, iodixanol, the LOCM, iopromide (both at 320 mg I/mL), mannitol solution with equal osmolality as iopromide, and dextran 500,000 solution with equal viscosity as iodixanol [44].
use and the occurrence of CIN between the LOCM iopamidol and the HOCM sodium diatrizoate, Schwab et al.
In summary, these studies do not convincingly demonstrate the decrease in risk for CIN between HOCM and LOCM that was anticipated for lowered osmolality CM.
Was NEPHRIC correct but used as a comparator a particular LOCM (iohexol) with a higher with a higher incidence of CIAKI?
When prospective randomized trials have specifically addressed patients undergoing contrast-enhanced CT, no differences have been found between IOCM and LOCM (Figure 3).