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Ellis and Cohan also proposed an SCr level of 2 mg/dL, below which the risk of CIN using LOCM appears low enough that no additional precautions are necessary for an indicated examination.
1,415,530 for a similar group of hospitals using LOCM exclusively.
The change in fatal reactions over the past 30 years from a rate of 1 in 30,000 injections to 1 in 170,000 likely reflects the increasing use of nonionic LOCM and the increased training of radiologists and radiology personnel about the recognition and treatment of reactions.