2,3,9-11) Oxidatively damaged Leydig cells
and Leydig cells
in aged testes exhibit suppression of antioxidant enzyme activities, reduced intracellular glutathione content, accelerated lipid peroxidation and oxidative modification of DNA, and loss of the mitochondrial membrane potential required for testosterone synthesis.
HLC, hypertrophied leydig cells
; TLC, total leydig cells
One juvenile granulosa cell tumor, 5 Leydig cell
tumors, and 3 Sertoli-Leydig cell
tumors were also tested for the same mutation for comparison.
Luteinising hormone (LH) was elevated, which may indicate subtle hormonal dysfunction of the Leydig cells
The testes contain three different types of cells namely Leydig cells
responsible for production of testosterone, spermatogonia responsible for spermatogenesis (sperm cells) and Sertoli cells responsible for secretion of androgen binding protein, inhibin, sulfated glycoprotein-2 and transferrin.
In male oxytocin is made locally within the testis and also possibly in epididymis and present in a interstitial Leydig cells
as a main source of testosterone [14,23].
CaR activation has been shown to stimulate PTHrP secretion from human breast cancer (MCF-7, MDA-MB-231) (108), prostate cancer (PC-3 and LnCaP) (109) and rat H-500 Leydig cells
The number of degenerating Leydig cells
increased by 97.
The interstitium was markedly hypocellular, and Leydig cells
were not identified.
2a], demonstrated the presence of galectin-3 in sections of mouse testis, predominantly in Leydig cells
In males, LH stimulates testosterone production from specialized cells called Leydig cells
A positive correlation between the proliferative changes in the Leydig cells
and an increase in serum LH levels (2-3 fold above control) has been demonstrated in both rodent species treated with high doses of finasteride.