4a,b) some seminiferous tubules with thick outline were shrunken and surrounded by congested interstitial tissue with number of
leydig cells, it was obvious that thickness in the interstitial tissue was induced due to the precipitation of fibers (Figs.
Characterization of insulin and insulin-like growth factor I receptors of purified
Leydig cells and their role in steroidogenesis in primary culture: a comparative study.
Animals subjected to physical exercise required a smaller number of sections to achieve a count of 1000
Leydig cells according to El-Sokkary (2001), whereas the quantitative results and nuclear volume of
Leydig cells showed a highly significant decrease in the mean number of cells mm-2 (unit area) and in the mean volume of nuclei in alcoholized rats versus controls.
The effect of exercise seems to be more prone in protecting seminiferous tubules (spermatogenic cell lineage and Sertoli cells) than
Leydig cells.
The amount of testosterone secreted per
Leydig cell was found to be much lower in male offspring after early-life exposure to BPA than in offspring from control unexposed animals.
Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat
Leydig cells in vitro.
In adult rat
Leydig cell cultures, both retinol and retinoic acid-enriched media showed a direct stimulatory effect on testosterone biosynthesis via 3[beta]-HSD compared to control media, as measured by radioimmunoassay.
Testis,
Leydig cells, Vervet monkey, Chlorocebus aethiops.
To ensure that inherent toxicity of our tested chemicals and their mixtures did not induce a downturn in testosterone synthesis, thereby confounding any genuine anti-androgenic effects, we assessed the functional integrity of the testosterone-producing
Leydig cell population by immunolabeling of cytochrome P450 (CYP11A1), a key enzyme of the androgen biosynthesis pathway.
NIS expression was localized in the lumen side of the seminiferous ducts and
Leydig cells but not observed in Sertoli cells with immunohistochemical examination (6).
This leads to the production of testosterone inside the
Leydig cells.
The apoptosis triggered by FA may be associated with caspase-3 activation, since a decrease of procaspase-3 accompanied with an increase of caspase-3 are discovered in MLTC-1 tumoral cells and TM-3
Leydig cells treated FA.
