2,3,9-11) Oxidatively damaged
Leydig cells and
Leydig cells in aged testes exhibit suppression of antioxidant enzyme activities, reduced intracellular glutathione content, accelerated lipid peroxidation and oxidative modification of DNA, and loss of the mitochondrial membrane potential required for testosterone synthesis.
HLC, hypertrophied
leydig cells; TLC, total
leydig cells.
One juvenile granulosa cell tumor, 5
Leydig cell tumors, and 3 Sertoli-
Leydig cell tumors were also tested for the same mutation for comparison.
Luteinising hormone (LH) was elevated, which may indicate subtle hormonal dysfunction of the
Leydig cells.
The testes contain three different types of cells namely
Leydig cells responsible for production of testosterone, spermatogonia responsible for spermatogenesis (sperm cells) and Sertoli cells responsible for secretion of androgen binding protein, inhibin, sulfated glycoprotein-2 and transferrin.
In male oxytocin is made locally within the testis and also possibly in epididymis and present in a interstitial
Leydig cells as a main source of testosterone [14,23].
CaR activation has been shown to stimulate PTHrP secretion from human breast cancer (MCF-7, MDA-MB-231) (108), prostate cancer (PC-3 and LnCaP) (109) and rat H-500
Leydig cells (108).
The number of degenerating
Leydig cells increased by 97.
The interstitium was markedly hypocellular, and
Leydig cells were not identified.
2a], demonstrated the presence of galectin-3 in sections of mouse testis, predominantly in
Leydig cells.
In males, LH stimulates testosterone production from specialized cells called
Leydig cells.
A positive correlation between the proliferative changes in the
Leydig cells and an increase in serum LH levels (2-3 fold above control) has been demonstrated in both rodent species treated with high doses of finasteride.
