Biallelic inactivation of the LHCGR causes Leydig cell
hypoplasia (LCH, OMIM#238320) that leads to male disorders of sexual differentiation (DSD).
Ameliorative effects of curcumin on the structural parameters of seminiferous tubules and Leydig cells
in metronidazole-treated mice: a stereological approach.
The submucosa is similar to the small intestine, composed of loose fibrous connective tissue containing many hemolymphatic vessels and Leydig cells
and superficial aggregations of hemocytes.
In this study, we demonstrated that purinergic and nitrergic systems interact in mice Leydig cells
. Our results show that the purinergic current amplitudes were not directly modulated by NO produced in basal conditions but that activation of NOS with L-arginine modified the ATP-induced current.
The Leydig cells
(arrows) were strongly immune-stained for StAR.
Caption: Figure 4: Nests of Leydig cells
with abundant eosinophilic cytoplasm and round nuclei; H&E at 400x.
Furthermore, leptin treatment of adult ob/ob males corrects their sterility, an effect that is mediated at least partly by a normalization in testicular weight, spermatogenesis, and Leydig cells
The authors of this study conclude that a hypogonadal state or Leydig cell
failure can be induced with zinc deficiency altering testicular steroidogenesis.
To ensure that inherent toxicity of our tested chemicals and their mixtures did not induce a downturn in testosterone synthesis, thereby confounding any genuine anti-androgenic effects, we assessed the functional integrity of the testosterone-producing Leydig cell
population by immunolabeling of cytochrome P450 (CYP11A1), a key enzyme of the androgen biosynthesis pathway.
The researchers reasoned that the direct conversion of adult skin cells into Leydig cells
would be a faster, safer regenerative medicine approach.
Cecchetto et al., "Ovarian Sertoli Leydig cell
tumours in children and adolescents: an analysis of the European Cooperative Study Group on pediatric rare tumors (EXPeRT)," European Journal of Cancer, vol.
TABLE 1: Serum testosterone level and the number of Leydig cells
were determined in the intact, diabetic-saline (Dia-Sa), diabetic-insulin (Dia-Ins), diabetic-omega3 (Dia-omg3), and diabetic-insulin-omega3 (Dia-Ins-omg3) groups, 35 days after the onset of DM.