4a,b) some seminiferous tubules with thick outline were shrunken and surrounded by congested interstitial tissue with number of leydig cells
, it was obvious that thickness in the interstitial tissue was induced due to the precipitation of fibers (Figs.
Characterization of insulin and insulin-like growth factor I receptors of purified Leydig cells
and their role in steroidogenesis in primary culture: a comparative study.
Animals subjected to physical exercise required a smaller number of sections to achieve a count of 1000 Leydig cells
according to El-Sokkary (2001), whereas the quantitative results and nuclear volume of Leydig cells
showed a highly significant decrease in the mean number of cells mm-2 (unit area) and in the mean volume of nuclei in alcoholized rats versus controls.
The effect of exercise seems to be more prone in protecting seminiferous tubules (spermatogenic cell lineage and Sertoli cells) than Leydig cells
The amount of testosterone secreted per Leydig cell
was found to be much lower in male offspring after early-life exposure to BPA than in offspring from control unexposed animals.
Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells
In adult rat Leydig cell
cultures, both retinol and retinoic acid-enriched media showed a direct stimulatory effect on testosterone biosynthesis via 3[beta]-HSD compared to control media, as measured by radioimmunoassay.
Testis, Leydig cells
, Vervet monkey, Chlorocebus aethiops.
To ensure that inherent toxicity of our tested chemicals and their mixtures did not induce a downturn in testosterone synthesis, thereby confounding any genuine anti-androgenic effects, we assessed the functional integrity of the testosterone-producing Leydig cell
population by immunolabeling of cytochrome P450 (CYP11A1), a key enzyme of the androgen biosynthesis pathway.
NIS expression was localized in the lumen side of the seminiferous ducts and Leydig cells
but not observed in Sertoli cells with immunohistochemical examination (6).
This leads to the production of testosterone inside the Leydig cells
The apoptosis triggered by FA may be associated with caspase-3 activation, since a decrease of procaspase-3 accompanied with an increase of caspase-3 are discovered in MLTC-1 tumoral cells and TM-3 Leydig cells