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Thiebaut's work [10] with synthetic traces demonstrated the structural importance of the locality of reference in real programs and its impact on hit and miss ratios.
Examples of transformations for optimization of locality of reference are scalar replacement, unroll-and-jam, loop interchange, tiling, memory copying, and data alignment.
The large data set with low locality of reference results in high data cache miss rates and low (less than 30%) effective utilization of a single-threaded processor.