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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
References in periodicals archive ?
Missense mutations are more common than loss-of-function mutations, and some of them cause just as much damage.
Harlequin ichthyosis (HI) is a severe variant of autosomal recessive congenital ichthyosis resulting from loss-of-function mutations in the ABCA12 gene on chromosome 2q35.
Seipin Loss-of-Function through Silencing or Knockout in Adipogenic Models.
This loss-of-function mutation appears to be novel as not present in ethnically diverse population databases (dbSNP, gnomAD, or ClinVar) nor in a locally maintained database of 100 ethnically matched individuals.
We now report two patients with diabetes diagnosed before 6 months of age: one with homozygosity for a novel ABCC8 nonsense variant and one with compound heterozygosity for the same nonsense variant and a previously reported loss-of-function missense mutation.
We had now moved into large-scale, human genetic studies and, because homozygosity for LPL loss-of-function mutations led to LPL deficiency and severely increased triglycerides, we thought that heterozygosity would lead to moderately increased triglycerides and increased cardiovascular disease risk, which was indeed the case (2, 3).
Individuals having loss-of-function mutations in the gene encoding this protein have very low plasma levels of cholesterol and triglycerides.
About a decade ago, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases.
Although filaggrin (FLG) loss-of-function mutations are the strongest and best-replicated genetic links to AD worldwide (outside of Africa), the specific FLG mutation spectrum has been found to differ among populations.
Biopharmaceutical company Epizyme (NasdaqGS:EPZM) said on Tuesday that the US Food and Drug Administration has filed its Investigational New Drug (IND) application for tazemetostat for the treatment of adults with mesothelioma characterized by BAP1 loss-of-function.
Examination of those people's exornes, the small portion of the genome that codes for proteins, revealed that among a subset of 821 participants, a total of 781 genes were rendered obsolete by "loss-of-function" mutations.