Moderate to severe GVHD Grades II-IV occurs in 30-50 percent of matched related hematopoietic stem cell transplants (HSCT) and 50-70 percent of matched unrelated donor
Two alternative non-family sources of stem cells are now used, namely matched unrelated donor
(MUD) transplants and umbilical cord blood transplants.
But infections that occurred after 30 days, primarily aspergillosis, candidiasis, and adenovirus, were far more common in children who received unrelated cord blood and matched unrelated donor
transplants than in children who received autologous or matched or partially-matched sibling transplants.
Seven adult subjects with hematologic malignancies undergoing matched unrelated donor
hematopoietic cell transplantation received ProTmune as the hematopoietic cell graft in the Phase 1 stage of PROTECT.