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He believes Newton and DeSalvo's counter-intuitive finding, that Sudoku matricies are more random than randomly-generated ones, is a "red flag".
Tests conducted before and after crude fractionation of the nondenatured VCP, using selective membrane (pore size) filtration as well as gel and bead matricies (see "Materials and Methods"), indicated that the cytolytic constituent(s) was between 50 and 100 kDa in size.
Alternatively, acellular dermal matricies (ADM) contain high amounts of elastin, which can remain in the patient's body and stretch unpredictably.