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This complex, referred to as the membrane attack complex or MAC, is composed of complement components C5b, C6, C7, C8 and C9.
By binding to a region of C5 corresponding to C5b, RA101495 also disrupts the interaction between C5b and C6 and prevents assembly of the membrane attack complex.
C8[alpha] is a 64 kDa subunit of human complement components C8, which is one of five components (C5b, C6, C7, C8, C9) that interact to form the cytolytic membrane attack complex of complement (MAC).

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