The
microglial cell transplantation in SCI rats using the micro-syringe method was simple and feasible.
Finally, abnormal
microglial cells are also associated with neurological disorders [92-94].
Some studies have already verified that anti-inflammatory drugs, such as ibuprofen, could alleviate CNS inflammation and inhibit the activation of
microglial cells [37, 38].
We have demonstrated that baicalin can modulate
microglial cell activation in vitro (Figure 7).
The enzyme responsible for the generation of ROI in an oxidative burst in
microglial cells is NADPH oxidase, which transfers an electron from a single cytoplasmic NADPH molecule to an oxygen molecule, producing superoxide anion ([O.sup.-.sub.2]).
Activated
microglial cells are also capable of producing both neurotrophic factors and antioxidants that can improve the neuronal function as well as neurotoxic cell signal factors [12-15].
Ko et al., "Activation of
microglial cells via protease-activated receptor 2 mediates neuronal cell death in cultured rat primary neuron," Nitric Oxide: Biology and Chemistry, vol.
Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and proinflammatory cytokine production in murine BV-2
microglial cells. Journal of Neuroinflammation 9, 260.
Dittel, "Development of a culture system that supports adult
microglial cell proliferation and maintenance in the resting state" Journal of Immunological Methods, vol.
Characterization of a novel brain-derived
microglial cell line isolated from neonatal rat brain.
Inhibition of
microglial cell activation by cortisol.
The microglial nodules consisted of small
microglial cells surrounding degenerative neurons (Figure 3).