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Minimum alveolar concentrations in man on awakening from methoxyflurane, isoflurane, ether and fluroxene anesthesia: MAC awake.
After a period of time in which the partial pressure of sevoflurane in the brain would have equilibrated with the alveolar partial pressure (6,7), the patient showed clinical signs of adequate anaesthesia and had an end-tidal sevoflurane concentration of more than 1 minimum alveolar concentration, but the entropy monitor still indicated an awake state.
Opioid agents significantly reduce the minimum alveolar concentration of potent inhaled anaesthetics required to facilitate intubation and improve overall intubating conditions during sevoflurane anaesthesia (5,6).

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