(2005) found 5 carriers out of 500 studied cows in Japan (0.5%
mutant allele frequency).Watanabe et al.
It is well known that different ethnic groups have their own distinctive and diverse PAH
mutant allele series that include one or a few prevalent founder alleles.
However, different clinical cutoffs have been proposed to discriminate between high- and low-risk patients with SM based on KIT D816V
mutant allele burden.
Analysis of alleles conferring resistance to antifolate drugs (Pfdhfr and Pfdhps) showed that the prevalence of
mutant alleles was generally high in field samples collected in 2003-2005 (Table 1).
Considering all genetic SNPs with a
mutant allele as input variables, the following SNP genotypes were found to be significantly positively associated with the risk of miscarriage: TLR9 AA (z = 4.180, p = 2.92e - 05), TLR9 GA (z = 4.184, p = 2.87 e - 05), IL-10 CA (z = 3.573, p = 0.000353), TLR2 GA (z = 3.027, p = 0.00247), and IL-8 CT (z = 2.862, p = 0.004205).
In 4 patients, only one
mutant allele was identified even after the use of direct sequencing and MLPA, these
mutant alleles being p.Asn380Lys, p.Arg1640Trp, and c.5714+5G>A (the latter in 2 patients).
Our study found that prevalence of the pfmdr1 N86Y
mutant allele has decreased and the Y184F
mutant allele has increased over time, in contrast with findings of other studies from Mozambique (34; references 55,58 in online Technical Appendix).
Out of these, five variations were found monomorphic for
mutant allele. Remaining animals were also homozygous both for wild and
mutant allele.
As part of the trial, the exploratory assessments include measuring changes in spleen size,
mutant allele burden, cytokines and bone marrow fibrosis over the course of treatment, added the company.
However,
mutant allele and genotype of FUT2 A385T were significantly increased in CD patients (49.27% versus 43.33%, P = 0.024, OR = 1.271, and 95% CI = 1.031-1.565; 27.64% versus 16.53%, P < 0.001, OR = 1.927, and 95% CI = 1.353-2.747, resp.) (Table 2).
The
mutant allele is more frequent among resistant than nonresistant patients (30% and 20.8%, resp.).
Consequently, fifteen healthy male Chinese subjects were totally enlisted, including eight homozygous subjects with the wild-type allele (FMO3 HHDD) and seven homozygous volunteers with the
mutant allele (FMO3 hhdd).
