Our study found that prevalence of the pfmdr1 N86Y
mutant allele has decreased and the Y184F
mutant allele has increased over time, in contrast with findings of other studies from Mozambique (34; references 55,58 in online Technical Appendix).
Allele frequency of all variations was calculated and very low frequency of
mutant allele was observed.
If the fetus had inherited the
mutant allele, an overrepresentation of mutant-linked haplotype would be observed in maternal plasma DNA.
Frequencies of CYP2D6
mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes.
The prevalence of Caucasians among
mutant allele carriers (70% Russians and other Caucasians), and the prevalence of Asians among normal homozygotes (53.
A, The relative average signal intensities of duplicate hybridization spots for the wild-type CYP2C9*2 allele plotted against the relative average signal intensities of duplicate hybridization spots for the
mutant allele are shown for all samples and positive controls (PCs) evaluated.
Resistance to HIV-1 infection in caucasian individuals bearing
mutant alleles of the CCR-5 chemokine receptor gene.
A course of moderate CA with recurrent exacerbations of prolonged character was personalized diagnosed when identifying the heterozygous genotype for the highly productive
mutant allele C/T of gene IL-1[beta] in polymorphic locus 3954.
Genotypes were determined as homozygous for the wild type allele (Ile/Ile; 176 bp), heterozygous (Ile/ Val; 176, 91, 85 bp) or homozygous for
mutant allele (Val/Val; 91, 85 bp).
The
mutant allele of Wx-B1 gene in DWHx12 is from a landrace, "Tammin" [20].
D2N-AHR/J mice expressing a
mutant allele deficient in ligand binding ([Ahr.
Interestingly, one study found that the rs1052133 wild type allele (C)-containing OGG1 has a seven-fold higher activity for repairing 8-oxoguanine than the rs1052133
mutant allele (G)-containing OGG1 (2), although two other studies could observe no association between OGG1 genotypes and enzyme activity (10,11).
