Mutation

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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
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(2005) found 5 carriers out of 500 studied cows in Japan (0.5% mutant allele frequency).Watanabe et al.
MOLECULAR SCREENING OF FXI DEFICIENCY GENE FRAGMENT IN NILI-RAVI BUFFALO BULLS OF PUNJAB, PAKISTAN
It is well known that different ethnic groups have their own distinctive and diverse PAH mutant allele series that include one or a few prevalent founder alleles.
Spectrum of Phenylalanine Hydroxylase Gene Mutations in Hamadan and Lorestan Provinces of Iran and Their Associations with Variable Number of Tandem Repeat Alleles
However, different clinical cutoffs have been proposed to discriminate between high- and low-risk patients with SM based on KIT D816V mutant allele burden.
Digital PCR: A Sensitive and Precise Method for KIT D816V Quantification in Mastocytosis
Analysis of alleles conferring resistance to antifolate drugs (Pfdhfr and Pfdhps) showed that the prevalence of mutant alleles was generally high in field samples collected in 2003-2005 (Table 1).
Effects of Drug Policy Changes on Evolution of Molecular Markers of Plasmodium falciparum Resistance to Chloroquine, Amodiaquine, and Sulphadoxine-Pyrimethamine in the South West Region of Cameroon
Considering all genetic SNPs with a mutant allele as input variables, the following SNP genotypes were found to be significantly positively associated with the risk of miscarriage: TLR9 AA (z = 4.180, p = 2.92e - 05), TLR9 GA (z = 4.184, p = 2.87 e - 05), IL-10 CA (z = 3.573, p = 0.000353), TLR2 GA (z = 3.027, p = 0.00247), and IL-8 CT (z = 2.862, p = 0.004205).
Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage
In 4 patients, only one mutant allele was identified even after the use of direct sequencing and MLPA, these mutant alleles being p.Asn380Lys, p.Arg1640Trp, and c.5714+5G>A (the latter in 2 patients).
Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles
Our study found that prevalence of the pfmdr1 N86Y mutant allele has decreased and the Y184F mutant allele has increased over time, in contrast with findings of other studies from Mozambique (34; references 55,58 in online Technical Appendix).
Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015
Out of these, five variations were found monomorphic for mutant allele. Remaining animals were also homozygous both for wild and mutant allele.
Molecular Phylogeny and Diversity Analysis of Hog Deer (Axis porcinus) in Pakistan
As part of the trial, the exploratory assessments include measuring changes in spleen size, mutant allele burden, cytokines and bone marrow fibrosis over the course of treatment, added the company.
Imago BioSciences doses first myelofibrosis patients with IMG-7289
However, mutant allele and genotype of FUT2 A385T were significantly increased in CD patients (49.27% versus 43.33%, P = 0.024, OR = 1.271, and 95% CI = 1.031-1.565; 27.64% versus 16.53%, P < 0.001, OR = 1.927, and 95% CI = 1.353-2.747, resp.) (Table 2).
Association of Fucosyltransferase 2 Gene Polymorphisms with Inflammatory Bowel Disease in Patients from Southeast China
The mutant allele is more frequent among resistant than nonresistant patients (30% and 20.8%, resp.).
Does i-T744C P2Y12 Polymorphism Modulate Clopidogrel Response among Moroccan Acute Coronary Syndromes Patients?
Consequently, fifteen healthy male Chinese subjects were totally enlisted, including eight homozygous subjects with the wild-type allele (FMO3 HHDD) and seven homozygous volunteers with the mutant allele (FMO3 hhdd).
Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers

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