In case of average mutations per individual, favorable mutation rate
per offspring is considered 0.01.
Southern Asia had a significantly higher exon 21 L858R mutation rate
compared with northern Asia.
The observed locus specific mutation rate
ranged between 0 for DYS19, DYS389I, DYS390, DYS391, DYS392, DYS393, DYS437, DYS348, DYS439, DYS448, DYS456, DYS458, DYS635, and Y-GATA-H4 loci and 1.765 x [10.sup.-3] (1.43 x [10.sup.-4] - 4.243 x [10.sup.-3]) for DYS385a locus at 95% CI .
The mutation rate
we found in Turkish patients (16.7%) is slightly higher than that reported in earlier studies on Caucasians.
Otherwise, the mutation rate
was increased to allow chromosomes to change towards a better population.
A high mutation rate
was observed in known drug-resistance markers such as pvcrt-o K10 AAG insert (66.6%, 14/21), pvdhps (100.0%, 20/20), pvdhfr (100.0%, 21/21), and pvmdr1 (100.0%, 21/21) (Table).
In the IGA-negative group, the -611 (G/A) mutation rate
was 88.3%, and the -56 (T/C) mutation rate
was 84.5% (-611 (G/A), -56 (T/C): 79 cases; -611 (G/A), -56 (T/T): 14 cases; -611 (G/G), -56 (T/C): 9 cases; and -611 (G/G), -56 (T/T): 3 cases).
The main parameters considered in this study are mutation rate
, size of the population, and number of generations.
Therefore, the lower mutation rate
presented in this study may be due to the regional difference or the smaller sample size.
Roughly the same mutation rate
was found in stem cells from organs with different cancer incidence, suggesting that accumulation of "bad luck" DNA errors over time doesn't explain the difference seen in cancer incidence, at least for some cancers.
(13) found an 8.0% prevalence of total and primary mutations among untreated CHB patients in China, and that Southern China had a little higher pooled total mutation rate
of 8.22% than Northern China 7.55%.