Moreover, the total number of
NK cells that express activation receptor NKG2D, involved in antitumor immune response, was notably lower in the lungs of tumor-bearing mice that received MSCs (Figure 5(b),p < 0.05).
These present data suggest that JTT inhibits B16 cell metastasis by inducing
NK cell activity.
Strategies based on the regulation of
NK cell function to treat CHB were only carried out in animal experiments so far.
Impaired
NK cell function in tumors is associated with the downmodulation of NCRs, which is said to be caused by ligand-induced receptor modulation, such as the shedding of ligands from the tumor cell surface, as shown in NKG2D [25].
Some studies have shown that halothane inhibits
NK cell activity in a dose-dependent manner.
Age induces changes in
NK cell functions [63] including a decreased
NK cell proliferation in response to IL-2 stimulation [84].
Our previous studies have showed that
NK cell and NKT cell infiltration was significantly decreased in the GC microenvironment, and that their levels were strongly associated with disease progression and patients' survival [3, 18].
All sections were covered with primary mouse anti-human
NK cell, [CD56.sup.+], monoclonal antibodies (Dako, Denmark) at a dilution of 1:100 for 30 minutes.
Table 1:
NK cell Achyranthes aspera Linn leaves extract Treatment
NK cell Dose X [+ or -] SD Control negative 7,53a [+ or -] 0,23 (Oilum olifarum) Control Positive 6,37c [+ or -] 6,40 (Chyclophosphamide) 6 mg [kg.sup.-1] P1 (CMC 0,5%) 3,90e [+ or -] 0,22 P2 (10 mg [kg.sup.-1]) 5,80d [+ or -] 0,28 P3 (30 mg k[g.sup.-1]) 6,47bc [+ or -] 0,42 P4 (100 mg [kg.sup.-1]) 6,77b [+ or -] 0,42 *) Values are mean [+ or -] standard deviation(n=10) **) Statistically significant difference in respect to the control P [less than or equal to] 0.05 (BNT 5 %)
Keywords:
NK cell cytotoxicity, Recurrent failed IVF, Soluble fms-like tyrosine kinase 1 (s-FLT-1), Vascular endothelial growth factor.
As the biological mechanisms for the elevated cancer incidence in overweight individuals still remained unclear, the aim of this studywas to characterize the relationship between an altered
NK cell functionality and the increased colon cancer risk in obesity.
To clarify if
NK cell functions are dependent on sex hormones, we used three different well-established human
NK cell lines: KHYG1 (originally from female), NK92, and NKL (originally from male), and stimulated them by sex hormones.
