Moreover, the total number of NK cells
that express activation receptor NKG2D, involved in antitumor immune response, was notably lower in the lungs of tumor-bearing mice that received MSCs (Figure 5(b),p < 0.05).
These present data suggest that JTT inhibits B16 cell metastasis by inducing NK cell
Strategies based on the regulation of NK cell
function to treat CHB were only carried out in animal experiments so far.
Impaired NK cell
function in tumors is associated with the downmodulation of NCRs, which is said to be caused by ligand-induced receptor modulation, such as the shedding of ligands from the tumor cell surface, as shown in NKG2D .
Some studies have shown that halothane inhibits NK cell
activity in a dose-dependent manner.
Age induces changes in NK cell
functions  including a decreased NK cell
proliferation in response to IL-2 stimulation .
Our previous studies have showed that NK cell
and NKT cell infiltration was significantly decreased in the GC microenvironment, and that their levels were strongly associated with disease progression and patients' survival [3, 18].
All sections were covered with primary mouse anti-human NK cell
, [CD56.sup.+], monoclonal antibodies (Dako, Denmark) at a dilution of 1:100 for 30 minutes.
Table 1: NK cell
Achyranthes aspera Linn leaves extract Treatment NK cell
Dose X [+ or -] SD Control negative 7,53a [+ or -] 0,23 (Oilum olifarum) Control Positive 6,37c [+ or -] 6,40 (Chyclophosphamide) 6 mg [kg.sup.-1] P1 (CMC 0,5%) 3,90e [+ or -] 0,22 P2 (10 mg [kg.sup.-1]) 5,80d [+ or -] 0,28 P3 (30 mg k[g.sup.-1]) 6,47bc [+ or -] 0,42 P4 (100 mg [kg.sup.-1]) 6,77b [+ or -] 0,42 *) Values are mean [+ or -] standard deviation(n=10) **) Statistically significant difference in respect to the control P [less than or equal to] 0.05 (BNT 5 %)
Keywords: NK cell
cytotoxicity, Recurrent failed IVF, Soluble fms-like tyrosine kinase 1 (s-FLT-1), Vascular endothelial growth factor.
As the biological mechanisms for the elevated cancer incidence in overweight individuals still remained unclear, the aim of this studywas to characterize the relationship between an altered NK cell
functionality and the increased colon cancer risk in obesity.
To clarify if NK cell
functions are dependent on sex hormones, we used three different well-established human NK cell
lines: KHYG1 (originally from female), NK92, and NKL (originally from male), and stimulated them by sex hormones.