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There are five classes of antiretroviral in use at present: NRTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transfer inhibitors (INSTIs), and entry inhibitors.
Tedavi gruplari incelendiginde NNRTI bazli kombinasyon kullananlarda %50 oraninda noropsikiyatrik yan etki goruldu.
Other new INSTIs, NNRTIs and PIs are currently being evaluated in phase I/II studies, as are improved formulations for delivery, such as injectable ARVs, including cabotegravir and rilpivirine.
In this study, levels of DRMs to PIs, NRTIs and NNRTIs were 27.6%, 3.7% and 40.7%, respectively.
PIs have a lower number of resistance mutations for reverse transcriptase enzymes compared to NNRTIs, which justifies this drug choice in preventing failure.
(24) As a way to further simplify ART, current clinical trials are looking at 2-drug regimens including an integrase inhibitor with an NRTI, an INSTI, or an NNRTI, or a PI with one NRTI.
The recommended regimen is based on two NRTIS (nucleoside reverse transcriptase inhibitor) plus an NNRTI (Non-nucleoside reverse transcriptase inhibitor) or boosted Protease inhibitor.
The "third drug" is a non-NRTI (NNRTI), a protease inhibitor (PI) or an integrase strand transfer inhibitor (INSTI).
Reduced susceptibility was not associated with sex, age, race, CD4 cell count, HIV RNA level, or NRTI, NNRTI, PI genotypic mutations but INSTI experience was significantly associated (p < .01).
Briefly, women with HIV-1 RNA <50 copies/mL, stable ART including two NRTIs (tenofovir or abacavir and emtricitabine or lamivudine) plus a PI or NNRTI, and central adiposity (waist circumference >94 cm or waist: hip > 0.88) were enrolled at five centers in North America from September 2008 to July 2010 and randomized 1:1 to switch their PI/NNRTI to open label RAL 400 mg twice daily (RAL arm) or continue to present ART for 24 weeks (PI/NNRTI arm).