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They found that adherence and magnitude of viral load decrease were predictive of sustained responses, while baseline CD4 T cell and viral load values and addition of NNRTIs to the regimen were not predictive.
The observed virologic failure rate in EDURANT treated subjects conferred a higher rate of overall treatment resistance and cross-resistance to the NNRTI class compared to efavirenz.
NNRTI treatment should be stopped immediately in anyone presenting with a rash and systemic symptoms.
There were no major NNRTI mutations observed in any of the patients at baseline.
Researchers randomly selected 229 people starting a first-line antiretroviral combination based on a PI, an NNRTI, or the integrase inhibitor Isentress at the Albany Medical Center HIV clinic.
INTELENCE is the first new NNRTI to be introduced in approximately 10 years.
Rilpivirine appears to retain antiviral activity against many of the single, double or triple NNRTI mutations.
Researchers used a meta-analysis to review 12 research trials comparing NNRTI to Pl, the two classes of antiretroviral drugs used in highly active antiretroviral therapy.
based in Cork, Ireland and now part of Johnson & Johnson, is a "second generation" NNRTI (non-nucleoside reverse transcriptase inhibitor)--an antiretroviral in the same class as efavirenz (brand name Sustiva, or Stochrin in many countries) or nevirapine (Viramune).
The FDA approves the NNRTI delavirdine (Rescriptor).
Four of the patients taking NNRTI regimens switched to PI therapy later in pregnancy, said Dr.
I found this particularly interesting because the current protease inhibitors and some NNRTI drugs are known to cause abnormal redistribution of body fat and potentially fatal liver toxicities.
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