NOAELs and LOAELs are limited to the dose groups tested in a particular study and are not informed by the shape of the dose-response relationship (Barnes and Dourson 1988; Travis et al.
Using a limited set of data and models, it was shown that BMDs based on a 5% extra risk response were within an order of magnitude of statistically derived NOAELs.
BMDs and BMDLs calculated using the method described here were compared to BMDLs and other PODs, particularly NOAELs, for the same chemicals as reported in previous human health assessments, using several linear regression methods to calculate Pearson ([R.
10/1Sd] were also compared with NOAELs from the same data set used as PODs in previous human health assessments, and, after log-transformation to account for skewness, were found to be significantly linearly correlated ([R.
Correlations of batch-calculated BMDs and BMDLs with BMDLs (A,B) and NOAELs (C,D) as reported in human health risk assessments.
Potential advantages of the BMDL relative to the NOAEL include the use of all available data in its determination and avoidance of the restriction that it be equal to one of the experimental doses.
The issue of what BMR may be appropriate as a starting point has been addressed to a certain extent by studies that have compared actual NOAEL and BMDL values across several data sets.
In addition, we describe an approach for deriving an RfD using the SNCD as the PoD and compare the resulting RfD to RfDs derived from the NOAEL and BMDL.
05); b) the NTP determined that the end point demonstrated "some" or "clear" evidence of carcinogenicity; and c) the data for the end point demonstrated a NOAEL according to the NTP poly3 p-value (p > 0.
Although all of these Agencies used the same occupational study (34) to derive the inhalation reference values, the values derived from this study were different and included NOAELs
, LOAELs, or benchmark doses as the point of departure for establishing the recommended levels.
Manufacturers say that human testing would set NOAELS that are specific to people, which would allow for more pesticide use while still protecting the population.