Immune surveillance of unhealthy cells by
natural killer cells.
Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in
natural killer cells.
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome.
The Localization and Migration of
Natural Killer Cells in Health and Disease
Interleukin-2 enhances the cytotoxic activity of circulating
natural killer cells in patients with chronic heart failure.
The researchers saw that lipoxin A4 encouraged
natural killer cells to decrease inflammation by facilitating eosinophil cell death.
Dr Adel Shaker of CARE said of the treatment: "We are surmising that it removes the dangerous signals from the immune system and can suppress the
natural killer cells.
It stimulates the white cell production, boosting the power of
natural killer cells and increasing antibody production.
Those cells package the resulting antigens with MHC proteins and present them to T cells,
natural killer cells, and other members of the immune system.
He concluded by saying that: "We now have a well-balanced portfolio of products, with three platforms - gamma delta T cells,
natural killer cells and TLR - bearing different risks and at different stages of development, as well as strong partners, including Novo Nordisk A/S, our exclusive R&D partner in the NK biology and one of our shareholders, which endorsed our position in the field of innate immunity".
According to the company, the NANT Cancer Vaccine is the first combination immunotherapy protocol to orchestrate the delivery of metronomic low-dose radiation and chemotherapy with molecularly-informed, tumor-associated antigen vaccines and
natural killer cells, to activate the innate and adaptive immune system and to induce immunogenic cell death.
This automated "GMP-in-a-Box" system will be utilized to develop next generation manufacturing for immune cells utilized in the treatment of cancer such as
natural killer cells.
