Immune surveillance of unhealthy cells by natural killer cells
Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells
Natural killer cell
dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome.
The Localization and Migration of Natural Killer Cells
in Health and Disease
Interleukin-2 enhances the cytotoxic activity of circulating natural killer cells
in patients with chronic heart failure.
The researchers saw that lipoxin A4 encouraged natural killer cells
to decrease inflammation by facilitating eosinophil cell death.
Dr Adel Shaker of CARE said of the treatment: "We are surmising that it removes the dangerous signals from the immune system and can suppress the natural killer cells
It stimulates the white cell production, boosting the power of natural killer cells
and increasing antibody production.
Those cells package the resulting antigens with MHC proteins and present them to T cells, natural killer cells
, and other members of the immune system.
He concluded by saying that: "We now have a well-balanced portfolio of products, with three platforms - gamma delta T cells, natural killer cells
and TLR - bearing different risks and at different stages of development, as well as strong partners, including Novo Nordisk A/S, our exclusive R&D partner in the NK biology and one of our shareholders, which endorsed our position in the field of innate immunity".
According to the company, the NANT Cancer Vaccine is the first combination immunotherapy protocol to orchestrate the delivery of metronomic low-dose radiation and chemotherapy with molecularly-informed, tumor-associated antigen vaccines and natural killer cells
, to activate the innate and adaptive immune system and to induce immunogenic cell death.
This automated "GMP-in-a-Box" system will be utilized to develop next generation manufacturing for immune cells utilized in the treatment of cancer such as natural killer cells