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BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
The oHSV rQT3 oncolytic virus showed remarkable in vivo xenograft results toward reducing endothelial progenitors to neuroblastoma and malignant peripheral nerve sheath tumors.
Key words: peripheral nerve sheath tumor, tetraplegia, nonambulatory, spastic tetraparesis, computed tomography scan, CT, myelography, magnetic resonance imaging, MRI, avian, golden eagle, Aquila chrysaetos
However, extremely rare childhood cases of neurofibroma, another benign nerve sheath neoplasm, and schwannomas of the clitoris, have been reported.
Malignant peripheral nerve sheath tumor (MPNST) and malignant triton tumor (MPNST with rhabdomyoblastic differentiation), potential candidates on morphologic grounds alone, arise often from a large peripheral nerve in patients with known neurofibromatosis.
The differential considerations for cystic intraneural lesions include cystic nerve sheath tumors, atypical Baker's cyst, and extraneural ganglion.
Schwannomas are non-invasive tumors arising from peripheral nerve sheaths and are encapsulated by epineurium.
Neurofibromas are most common, manifesting as heterogeneous, benign, peripheral nerve sheath tumours after the second decade.
Schwannoma is a benign nerve sheath tumor originating from the normal peripheral nerve, which is composed of neoplastic cells demonstrating features of constituent Schwann cells of the normal peripheral nerve sheath.
Both patients and care providers are willing to participate in clinical trials for NF1 and both groups rate malignant peripheral nerve sheath tumors as the most urgent for new treatments.
The information is presented in chapters covering benign peripheral nerve sheath tumors (neurofibromas, schwannomas, and perineuriomas); malignant peripheral nerve sheath tumors; meningioma; hemangioblastoma of the central nervous system; paraganglioma and pheochromocytoma; atypical teratoid/rhabdoid tumors of the central nervous system; neuroblastoma and related tumors; medulloblastoma, primitive neuroectodermal tumors, and pineal tumors; and key mechanisms and pathways.