Pathologic examination of specimens showed intra-alveolar localized neuroendocrine cell
proliferation and minimal interstitial fibrosis under the bronchial epithelium and in the parenchyma [Figure 5].
Chromogranin A is a 439-residue-long glycoprotein [15,16], a member of a larger family of soluble secretory proteins (granin proteins) that includes also chromogranin B (CgB), secretogranin (Sg) II (CgC), Sg III (1B1075), Sg IV (HISL-19), Sg V (7B2) and Sg VI (NESP55), Sg VII (VGF), and Sg VIII (proSAAS) , localized in secretory granules of neuroendocrine cells
, neurons, and the adrenal medulla .
Smedts et al., "Neuroendocrine cells
during human prostate development: does neuroendocrine cell
density remain constant during fetal as well as postnatal life?" Prostate, vol.
are frequently found in the bile ducts and, therefore, could be expected in cholangiocarcinoma.
Pulmonary neuroendocrine cells
(PNEC) play an important role in the developmental process of the lung and therefore seem to be present in greater amount in children's lungs as compared to adults [18,19].
Neuroendocrine tumours (NETs) is an umbrella term for a group of uncommon cancers that arise from neuroendocrine cells
. These cells are most commonly found in the mucosa lining the gastro-intestinal tract, the lungs and bronchi, and in endocrine organs, such as the thyroid and adrenal glands.
The respiratory epithelium composed of tall columnar ciliated, goblet cells, basal cells, and neuroendocrine cells
"This is a very significant demonstration of how neurons and likely other neuroendocrine cells
package neuropeptides, move them around the cell, and release them where they will be most effective," said Michael Sesma, Ph.D., of the National Institute of Health's National Institute of General Medical Sciences, which partially funded the research.
Carcinoid tumours originate from neuroendocrine cells
and thus can have endocrine activity.
(15) Orexins are also expressed in the neuroendocrine cells
scattered in the glandular and lining epithelia of the gastrointestinal system.
A villiform growth pattern is observed containing goblet cells with mucous cells, Paneth cells and neuroendocrine cells
. (1), (3) Mature absorptive intestinal cells with a brush border are rare.
GFI1 plays a key role in several developmental processes, including the formation of blood cells, pulmonary neuroendocrine cells
, and the inner ear.