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Biopharmaceutical company Catalyst Biosciences (NasdaqCM:CBIO) disclosed on Tuesday the launch of a definitive agreement to sell one of its neuronal nicotinic receptor (NNR) assets for an upfront payment of USD750,000.
2 Role of alpha-7 nicotinic receptors in brain development
Varenicline-Nicotinic Receptor Partial Agonist: Varenicline is a nicotinic receptor partial agonist acting mainly on the [alpha][beta][beta]2 subtype of the nicotinic cholinergic receptor.
BOSTON -- An investigational nicotinic receptor agonist demonstrated cognitive benefits similar to those seen with donepezil in a phase II trial of patients with mild to moderate Alzheimer's disease.
They found that inactivation of beta2 subunit, a specific sub-class of nicotinic receptors that bind nicotine, appears to reduce anxiety.
The actions of acetylcholine in the periphery are the result of activation of either inotropic nicotinic receptor or the metabotropic muscarinic receptor (Caufield and Birdsall, 1998).
Greater accumulation of beta amyloid "plaques" was accompanied by a reduction in neuronal nicotinic receptors - brain molecules crucial to memory function.
The $200 million payment comes for the drug candidate TC-5214, a nicotinic channel blocker that is thought to treat depression by acting on neuronal nicotinic receptors, or NNRs.
Nicotine is a naturally occurring alkaloid that is capable of stimulating acetylcholine receptors in both the sympathetic and parasympathetic systems, as well as cholinergic nicotinic receptors at skeletal muscle sites and in the brain.
In this case, the past dates back to the late 1980s, when researchers began to realize the breadth of the brain's inventory of nicotinic receptors.
This study provides the first substantive clinical evidence that compounds where the primary pharmacology is antagonism to neuronal nicotinic receptors will have antidepressant properties," said Dr.
Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects.