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BOSTON -- An investigational nicotinic receptor agonist demonstrated cognitive benefits similar to those seen with donepezil in a phase II trial of patients with mild to moderate Alzheimer's disease.
They found that inactivation of beta2 subunit, a specific sub-class of nicotinic receptors that bind nicotine, appears to reduce anxiety.
Individual alkaloids, ajmalicine, catharantine, and serpentine, were tested for their ability to antagonize nicotinic receptors at the neuromuscular junction.
However, unlike the lonely years of the 1990s, it's now difficult to find a major drug company not trying to capitalize on nicotinic receptors,
Nicotinic receptor stimulation leads to tachycardia, hypertension, mydriasis, fasciculations and muscle weakness, as well as respiratory failure.
Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects.
Articles integrate molecular and neurochemical approaches to behavior applications in animal models and clinical applications with cutting-edge research in such topics as pharmacologic models (muscarinic receptor antagonists and nicotinic receptors in rats, animal models and the cognitive effects of ethanol, toxocologic models (lead exposure, methylmercury, PCBs, MPTP), mouse genetic models (transgenic mouse models of amyloid deposition, cholinergic receptor knockout mice, mutant mice) and model applications and future developments (pharmacology in aging macaques, traumatic brain injury, models using complementary species and cognition models and drug discovery).
Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning.
Varenicline is pharmacologically known as an alpha4beta2 nicotinic acetylcholine receptor partial agonist, which means that it activates the brain's nicotinic receptors in a manner similar to nicotine, but with less affinity (effect).
It seems that the nicotinic receptors are the ones that go.
However, unlike other therapies, research indicates that Reminyl has a second mechanism of action: it acts on nicotinic receptors in the brain.