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Nucleus pulposus ADC values were recorded from the 12 points of the center area, and the mean was calculated.
Condoliase is being developed for use as a chemonucleolysis treatment to break down selected components of the IVD, primarily within the nucleus pulposus.
The nucleus pulposus part of the intervertebral disc is formed from the notochord cells while the annulus fibrosus develops from the mesenchymal cells.
Abbreviations A: Annexin V-FITC AF: Annulus fibrosus Akt: Protein kinase B EGCG: Epigallocatechin 3-gallate IL: Interleukin IVD: Intervertebral disc JC-1: 5,5',6,6'-Tetrachloro-1,1',3,3' tetraethylbenzimidazolcarbocyanine iodide LY: LY294002 MMP: Matrix metalloproteinase MTT: 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide NF-[kappa]B: Nuclear factor kappa-light-chain-enhancer of activated B cells NP: Nucleus pulposus PI: Propidium Iodide ROS: Reactive oxygen species SA [beta]-gal: Senescence-associated [beta]-galactosidase SASP: Senescence-activated secretory phenotype.
In 1929, Schmorl reported his observation of "nodules" associated with the disc; he believed them to be a result of a prolapsed nucleus pulposus and associated with a degenerative or traumatized annulus fibrosus.
The nucleus pulposus was modeled such a way that it occupied 43% of the total area of the disc [1].
The weakness and degeneration of fibrous ring and posterior longitidunal ligament may cause posterior herniation of nucleus pulposus towards the spinal canal.
The increase in disc height was due to restoration in the transplant group of the nucleus pulposus structure, which refers to the jelly-like substance in the disc, and an increased amount of water content, which is critical for the appropriate function of the disc as a cushion for the spinal column, the researchers concluded.
Back & Spine - Back pain & Stiffness,Arthritis of the spine,Sciatica,Slipped Disc,Spinal Narrowing,Spinal Stenosis,Spondylitis,Spondylolisthesis,Spondylosis,Herniated Disc,Bulging Disc,Canal Stenosis,Failed back surgery syndrome,Pinched nerve,Foraminal narrowing,Foraminal stenosis,Herniated Nucleus Pulposus
Anterior microdiscectomy was performed in C5-C6, removing bulky intervertebral disc consisting of the nucleus pulposus and annulus fibrosus.
The disc joint is composed of three major parts: cartilaginous vertebral endplates that cap the bodies of the vertebrae, a fibrous annulus fibrosus that is located circumferentially between the vertebral bodies, and a thick gel-like nucleus pulposus in the center bounded by the fibers of the annulus fibrosus.
Though the mechanism is still not certain, animal studies indicate that when there is nucleus pulposus tissue in the epidural space, it induces an inflammatory response, neurotoxicity, and thrombosis, all of which can lead to nerve root ischemia and irritation.

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