The reports included 80 cases of metabolic acidosis or ketosis, 43 cases of obtundation
or confusion, 17 cases of pancreatitis or hyperamylasemia, and 13 patients who died during or shortly after the hyperglycemia episode.
The most common symptoms and signs were nausea/vomiting (10 [71%]), obtundation
(nine [64%]), bradycardia (seven [50%]), prolonged unconsciousness (six [43%]), syncope (six [43%]), seizures (four [29%]), confusion (four [29%]), combativeness (four [29%]), respiratory depression (three [21%]), amnesia (two [14%]), and euphoria (two [14%]).
Glucose depletion to the brain rapidly causes impaired neuronal function, manifested by cognitive impairment or depression of level of consciousness, exhibited as obtundation
, stupor or coma.
50) Patients can have a range of neurologic symptoms including headaches, nausea, vomiting, disorientation, seizures, obtundation
, or even coma.
Neonates who developed CSF abnormalities before first hospital discharge were excluded, as were persons with a physician-documented diagnosis of encephalitis, confusion, or obtundation
He rapidly developed hypotension, obtundation
, and bradycardia.
lasting greater than 24 hours has occurred infrequently in .
6 [micro]g/kg body weight intravenously can be used for obtundation
of rise in IOP associated with suxamethonium, laryngoscopy and endo tracheal intubation in patients where rise in IOP can be detrimental.
Complaints or historical elements inconsistent with concussion that should be considered red flags include any focal neurologic complaints, vomiting or headache that worsens after a period of improvement, or obtundation
or disorientation that has worsened since the injury.
The third and fourth stages include increasing obtundation
, amnesia, nystagmus, clonus, and muscular rigidity and may progress to coma, decerebrate posturing, dilated pupils, and poor response to painful stimuli.
Our patient had obtundation
and delirium that persisted after doxycycline therapy was initiated and his fever had resolved.