The CSF and serum tests in each group included aquaporin-4-antibodies (AQP4-Ab), myelin oligodendrocyte glycoprotein antibodies (MOG-Ab), myelin basic protein (MBP), specific oligoclonal bands
(SOBs), total white blood cell count in CSF, and CSF biochemistry examination.
Cerebrospinal fluid examination was normal, except for the slightly elevated protein level and presence of a single oligoclonal band
His paired cerebrospinal fluid (CSF) and serum samples were sent to the clinical biochemistry laboratory for oligoclonal band
analysis by CSF isoelectric focusing and IgG immunofixation (Fig.
Strong evidence in support of the humoral basis of MS is the intra-CFS synthesis of oligoclonal bands
5) Cerebrospinal fluid abnormalities, such as the presence of oligoclonal bands
, are not always present and are not necessarily specific to the diagnosis.
The significance of oligoclonal bands
in multiple sclerosis: relevance of demographic and clinical features, and immunogenetic backgrounds.
1) In 2010, the College of American Pathologists (CAP) began offering a new proficiency survey on oligoclonal bands
, OLI, which includes paired CSF and serum samples for laboratories performing these assays.
A lumbar puncture showed elevated protein and oligoclonal bands
In addition to 1 year of disease progression, the new PPMS criteria require two of the following: at least one T2 lesion in at least one area characteristic for MS (periventricular, juxtacortical, or in-fratentorial); at least two T2 lesions in the cord; or positive cerebrospinal fluid (isoelectric focusing evidence of oligoclonal bands
with or without an elevated IgG index).
Cerebrospinal fluid examination showed no oligoclonal bands
and magnetic resonance imaging of the spine was normal.
CSF examination was again undertaken and was positive for oligoclonal bands
IgG index and oligoclonal bands
were within normal limits.