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Some have pointed to a possible connection between human penile ossification and the normally occurring os penis in animals.
In humans, the os penis seems to have been acquired during the aging process because almost all of the cases were observed in 50- to 80-year-old men.
Despite the early theories of an evolutionary explanation for the few cases of human penile ossification, more contemporary authors have theorized that there is no relationship between the rare ossification seen in certain parts of the fibrous structures of the human penis and the os penis seen in animals.