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Pharma pipelines and disease indications addressed by PDE inhibitors aid review of their therapeutic potential.
Assess the therapeutic potential of PDE inhibitors by identification of the major disease indications addressed by approved PDE inhibitors and those in clinical development.
15) The findings of this study were presented by the authors as the potential mechanism by which PDE inhibitors can impact LUTS and BPH.
The effect of specific PDE inhibitors (PDE 1,2,4 and 5 inhibitors) on the contraction of prostatic tissue induced by a vasocon-strictor peptide (endotethelin-1) were also analyzed by the organ bath technique.
This is an affirmation of VIVUS' initial opposition of Pfizer's method of use patent for PDE inhibitors to treat ED and confirms the decision of the Opposition Division of the European Patent Office, which ruled Pfizer's method of use patent to be invalid," stated Dr.
VIVUS holds broad patents for the use of types 3, 4, and 5 PDE inhibitors for transuretheral delivery to treat erectile dysfunction.
Moreover, the majority of PDE inhibitors investigated to date do not induce apoptosis in tumor cells.
The first was a patent issued in March 2000 for PDE5 inhibitors, a class of PDE inhibitors that includes sildenafil citrate, commonly known as Viagra(R).
Until now, PDE inhibitors have not been developed as anti-cancer agents.
PDE4 inhibitors show the same potency in animal models as PDE5 inhibitors, however, their actual benefit may be in limiting the cardiovascular side effects seen with other PDE inhibitors," said Leland F.
Animal studies conducted at Tulane University, New Orleans, LA, and published in the November 1999 Journal of Urology, have demonstrated the combination of alprostadil and PDE inhibitors delivered transurethrally was as effective as a needle injection of a "triple-mix" (alprostadil, phentolamine and papaverine) into the penis for producing erections.
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