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Related to PDE inhibitor: phosphodiesterase type 5 inhibitors, PDE5
See: deterrent
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Get an up-to-date perspective on PDE inhibitor targets with a systematic review of each PDE family.
TABLE 1 Selectivity ratios of PDE inhibitors Sildenafil Vardenafil Tadalafil PDE1 80 257 >10,000 PDE2 >7500 >10,000 >10,000 PDE3 4400 3600 >10,000 PDE4 1800 5700 >10,000 PDE5 1 1 1 PDE6 10 224 780 PDE7 5160 No data >10,000 PDE8 >10,000 No data >10,000 PDE9 2796 No data >10,000 PDE10 1123 447 >10,000 PDE11 346 203 5.
Oral PDE inhibitors, approved for adults in psoriasis, may have utility in AD.
It is notable that this activity is comparable to that of zaprinast, which is one of the few cGMP-specific PDE inhibitors (Sugita and Black, 1998).
Vivien Mak, Vice President of Research at Cellegy, commented, "Over the past two weeks, Cellegy has been issued two important United States patents (covering the use of PDE inhibitors and potassium channel openers) that result from our ongoing efforts to develop products for the treatment of fissures and hemorrhoids.
1182/blood-2009-11-252668, CombinatoRx researchers, in collaboration with the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, demonstrate the powerful and unexpected synergistic interactions of A2A Agonist and PDE Inhibitors as potential adjunctive therapy to glucocorticoid (GC) containing regimens in the treatment of multiple myeloma (MM) and other B-cell malignancies.
The PDE inhibitors covered in the present patent include those which decrease or abolish the activity of PDE 3, PDE 4 and PDE 5.