6% of the overall population achieved a PSA response
of 50% or greater; the predefined lower limit of 10% of the one-sided CI was 47.
A post-hoc analysis was conducted in Canadian patients after the database was locked to evaluate the impact of the prior use of abiraterone on cabazitaxel's efficacy assessed based on PSA response
, QoL, and safety.
rates were also statistically significantly higher with docetaxel compared to mitoxantrone.
The PSA response
rate of 36% compares favour-ably to the 29% rate seen in COU-AA-301 and underlines the biochemical effectiveness of this therapy.
Raya Leibowitz-Amit and colleagues studied the association between abiraterone dose, PSA response
and progression-free survival (PFS) by means of a retrospective review of all men receiving abiraterone at their institution from November 2009 to March 2013 (n = 111).
7] PSA response
, pain reduction and improvement in quality of life.
Survival and PSA response
of patients in the TAX 327 study who crossed over to receive docetaxel after mitoxantrone or vice versa.
Overall survival was also analyzed after stratifying patients by PSA response
(50% decline from baseline) and by PSAHL at 42 days postdocetaxel and at 84 days post-docetaxel initiation.
Using the American Society for Therapeutic Radiation and Oncology (ASTRO) standard criteria to monitor PSA response
for reporting disease free survival, the cure rate was 90.
This will be the first release of information regarding PSA response
to Cesium-131 brachytherapy seeds.
Of the patients evaluated for PSA response
, two patients achieved a 50% or greater decrease in PSA, with another patient achieving a 40% fall in PSA.
Of the 29 efficacy evaluable patients, one patient with anaplastic thyroid carcinoma had a partial response, one patient with hormone refractory prostate cancer demonstrated a confirmed partial PSA response
, and 18 patients had disease stabilization.