and coeliac disease-quantitative, morphometric analysis.
Knockout mice that lack Paneth cells
do not show any increase in microvasculature despite induction with gut microflora (46).
The Paneth cell
is at the heart of another microbe-intestine interaction uncovered recently by Gordon's group.
Enteroendocrine cells are terminally differentiated cells, which together with Goblet cells and Paneth cells
constitute the secretory cell types in the small intestine lineages whilst 90% of the healthy epithelium is lined by absorptive columnar cells.
Third, the presence of Paneth cells
distal to splenic flexure indicates a metaplastic process and suggests chronicity (Figure 1, C).
defensins: Endogenous peptide components of intestinal host defense.
Researchers at MIT and Brigham and Women's Hospital found a way to replace Paneth cells
with two small molecules that maintain stem cells and promote their proliferation.
It's up to the stem cells, which dwell just above the Paneth cells
, to spawn progeny that migrate onto the tips of fingerlike villi that line the intestine and absorb nutrients.
Small intestine biopsy with complete villous blunting, chronic inflammation, prominent crypt epithelial injury, and loss of Paneth cells
and goblet cells (hematoxylin-eosin, original magnification X100).
are numerous in the deeper parts of the intestinal crypts, particularly in the duodenum.
Intestinal-type adenoma, the most common type of neoplastic polyp in the upper gastrointestinal tract, consists of intestinal-type absorptive cells, with a variable admixture of goblet and/or Paneth cells
39) Paneth cells
are commonly seen within the tumors, and extracellular mucin may be present.