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Related to Paratope: agretope, Idiotope
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In this study, we isolated peptides binding specifically with the paratope regions of six PSA MAbs and studied their reactivity with a large panel of PSA antibodies.
Knowledge of the chemistry of the antigen-antibody reaction, the contribution of different binding forces, the spatial orientation of critical elements of the molecular structure, and the ultimate definition of definitive epitope and paratope regions has been gleaned from fundamental techniques such as x-ray diffraction, nuclear magnetic resonance, elipsometry, and mass spectrometry (8), together with the experience gained from the clinical application of assays and their subsequent refinement.