We believe this finding may be due to the fact that these populations share characteristics like advanced cancer stages, age, and low performance status
. Although we used a different instrument to diagnose delirium (CAM) than the one used in other studies from acute palliative care services (Memorial Delirium Assessment Scale), previous studies have demonstrated no significant differences among different delirium diagnostic scales (Wong, Holroyd-Leduc, Simel, & Straus, 2010).
Abbreviations mPC: Metastatic pancreatic cancer NLR: Neutrophil to lymphocyte ratio OS: Overall survival NSCLC: Nonsmall cell lung cancer CRC: Colorectal cancer PFS: Progression-free survival PS: Performance status
CI: Confidence interval HR: Hazard ratio IL-2: Interleukin-2 IL-6: Interleukin-6 IL-10: Interleukin-10 TNF-[alpha]: Tumor necrosis factor a VEGF: Vascular endothelial growth factor.
Pretreatment data of all patients was collected regarding demographics and clinical variables including age, gender, height, weight, performance status
, body surface area, cancer type, disease stage and planned chemotherapy treatment including drugs, doses and schedule.
As shown in Table 2, in univariate analysis, decreased OS and PFS rates correlated with high IPI score (both p < 0.001), advanced Ann Arbor stage (both p < 0.001), poor performance status
(both p <0.001), and elevated LDH level (both p < 0.001) as well as cytokines IL-2R (both p < 0.001), IL-6 (p < 0.001 and p = 0.004, resp.), IL-10 (both p <0.001), and TNF-[alpha] (p = 0.003 and p = 0.005, resp.).
A nominally significant association with shorter TTP was observed in carriers of polymorphic MMP14 rs1042703 allele when compared to noncarriers, but only after adjustment for histological type, weight loss, and performance status
(HR= 1.44, 95% CI= 1.01-2.03, p = 0.042).
Patients with pancreatic cancer typically have a poorer performance status
than those with gastric cancer and cannot tolerate the major tissue damage associated with open surgery.
In this prospective, observational study in patients with lung cancer, we found that HIV-positive patients were younger, more likely to have squamous cell carcinoma and significantly more likely to have a poor ECOG performance status
of [greater than or equal to] 3 at presentation.
For work performance status
, DMW was assessed by asking respondents how many days they had missed from work due to cardiovascular disease in the previous 4 weeks.
Age at diagnosis, race, sex, histology, sites of metastases, date of diagnosis, performance status
and date of chemotherapy initiation were collected.
In addition, the patient did not undergo consolidation due to poor performance status
. Eventually the patient was treated with decitabine as palliative therapy in a patient with poor performance status
On review at his first medical oncology appointment, his overall condition and performance status
had improved significantly.