Novel mechanism associated with an inherited cardiac arrhythmia: defective protein in trafficking by the mutant HERG (G6015) potassium channel
Slow potassium channels
are activated during sustained depolarization and high-frequency discharge and modulate repetitive firing patterns.
We found that the addition of excess KCl to the seawater stimulated settlement and metamorphosis, whereas this effect was negated by simultaneous addition of the potassium channel
blocker tetraethylammonium chloride (TEA).
Expression of the calcium-activated potassium channel
in upper and lower segment human myometrium during pregnancy and parturition.
Abbreviations SUR: Sulfonylurea receptor IPC: Ischemic preconditioning IR: Ischemia-reperfusion KCO: Potassium channel
opener 5-HD: 5-Hydroxydecanoate ROS: Reactive oxygen species STV: Isosteviol NAC: N-Acetyl-cysteine APD: Action potential duration DNP: Dinitrophenol RMP: Resting membrane potential PKC: Protein kinase C AMPA: AMP-activated kinase.
In conclusion, dihydrospinochalcone-A induces a significant antihypertensive effect due to its direct vasorelaxant action on rat aorta rings, through NO/sCG/PKG pathway and potassium channel
are downregulated on the pulmonary artery smooth muscle cells of patients with PAH, suggesting a therapeutic role for a potassium channel
In in vitro experiments using a rat pituitary cell line, Armstrong's team found that thyroid hormone stimulates potassium channel
activity through a signal transduction cascade that involves PI3 kinase and Rac GTPase.
A research team has now obtained the first atomic-scale portrait of one of these crucial gatekeepers, a voltage-dependent potassium channel
FAMPYRA is an oral potassium channel
blocker which is thought to work by stopping potassium leaving the nerve cells which have been damaged by MS.
These relaxation responses were not altered by the pretreatment of inhibitors of endothelium-related dilator synthases, cGMP and cAMP pathway inhibitors, potassium channel