Effects of anandamide on potassium channels
in rat ventricular myocytes: a suppression of 1(to) and augmentation of K(ATP) channels.
Utilising its world-leading expertise in the discovery of potent and selective drugs, Xention is focusing on the potassium channels
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel
Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel
by isoflurane and halothane.
The company's portfolio of products is targeted at the ATP-sensitive potassium channel
, a metabolically-regulated membrane protein whose modulation has the potential to impact a wide range of cardiovascular and metabolic diseases.
In this family, the primary pore forming [alpha] subunit has two pore domains and forms functional dimers in contrast to the usual potassium channel
The effects of potassium channel
gene regulation on ion currents, protein density, and the cardiac action potential have been demonstrated previously.
Identifying the channel for water and determining the structure of the potassium channel
led to insights into cellular function and diseases of the kidney, heart, muscle, and nervous system, notes the Nobel academy.
The book also has excellent in-depth coverage of other approaches in pain therapy, such as gabapentin, gabapentinoids, sodium channel blockers (including antiepileptic drugs such as phenytoin, carbamazepine, and lamotrigine and antiarrhythmic drugs such as mexiletene), potassium channel
blockers, and calcium channel antagonists.
A second type of pore-like molecule is the potassium channel
20,22] This gene was found to be a novel potassium channel
gene, initially called KVLQT1 and later renamed KCNQ1.
demonstrated that a potassium channel
blocker, 4-aminopyridine (4-AP), can temporarily improve some neurological symptoms such as gait ataxia and weakness.