To date, only treatments with limited efficacy or restrictive safety issues are available to treat preterm labor
. In the United States, no drugs are approved for acute treatment of PTL and recommended off-label tocolytic treatments (medications that inhibit labor) include beta-adrenergic receptor agonists, calcium channel blockers, or NSAIDs, which are used for short-term prolongation of pregnancy (up to 48 hours) to allow for the administration of antenatal steroids (e.g.
Uterine artery pulsatility index during peak uterine contraction in women with threatened preterm labor
was found significantly higher in women who delivered within 7 days .
Kusanovic, "Nifedipine in the management of preterm labor
: a systematic review and metaanalysis," American Journal of Obstetrics & Gynecology, vol.
Srinivas et al., "Clinical prediction rules for preterm birth in patients presenting with preterm labor
," Obstetrics and Gynecology, vol.
Our study indicated that maternal serum magnesium level was associated with preterm labor
. In addition, there was a direct correlation between maternal serum magnesium level and gestational age and neonatal weight.
Women with history of preterm labor
, preterm premature rupture of membranes ( PPROM), in utero diethylstilbestrol (DES) exposure, or collagen disorders (e.g., Ehlers-Danlos syndrome), cervical lacerations during labor and delivery and cervical injuries due to gynecologic procedures are at risk of premature labor.11,12
Indicators measured were adverse obstetric outcomes (preterm labor
, pregnancy-induced hypertension [PIH], placenta previa, placental abruption, fetal growth restriction [FGR], small for gestational age [SGA], cesarean section), and luteal support in the first trimester.
A number of studies have reported increased concentrations of certain cytokines, most notably interleukin 6 (IL-6) in the serum and amniotic fluid of patients with preterm labor
Fetal fibronectin (fFN), the current preterm labor
diagnostic test, is easily influenced by factors that can provide false results; therefore, many women are ineligible for fFN testing.
Poor housing, low maternal education and low income are significantly associated with preterm labor
Evaluation of preterm labor
markers, which induce clinically silent inflammation, may increase the effectiveness of detection and treatment of preterm delivery .
Watts and colleagues studied the amniotic fluid (AF) samples of women with intact membranes in idiopathic preterm labor