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Related to Prothrombin complex concentrate: cryoprecipitate, Prothrombin time, Activated prothrombin complex concentrate
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Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers.
Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.
Octapharma AG, a human protein products manufacturer, announced on Wednesday the signing of an agreement with Pfizer Inc (NYSE:PFE) for the future marketing and commercialisation of human prothrombin complex concentrate (PCC), an investigational agent currently under FDA review for the urgent reversal of Vitamin K antagonist (VKA) therapy in adult patients who require urgent surgery or invasive procedures.
Approved by the FDA in April this year,for the immediate reversal of warfarin therapy in adult patients with critical major bleeding, Kcentra, is the sole non-activated 4-factor prothrombin complex concentrate (4F-PCC) indicated in the US for these uses.
Fresh frozen plasma, prothrombin complex concentrates, and recombinant activated factor VII have been used to treat acute hemorrhage in FV inhibitor cases with varying outcomes.
10,11) Avail able replacement options include FFP, plasma derived factor VII concentrates, prothrombin complex concentrates and recombinant-activated factor VII (rFVIIa).
Treatment strategies to control active bleeding include the use of factor VIII concentrates, activated prothrombin complex concentrates (anti-inhibitor coagulant complex, Feiba, Autoplex T), and recombinant human factor VIIa (6), (8), (9).
However, while warfarin's effects can be reversed with vitamin K, fresh frozen plasma, or prothrombin complex concentrates, no proven antidotes have been developed to counter the new drugs in people experiencing excessive bleeding.
FVII can be temporarily supplemented by infusing fresh frozen plasma, prothrombin complex concentrates containing factors X, IX, VII, and II derived from plasma, and recombinant FVIIa (NovoSeven[R]).

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