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This condition which was described by West in 1841 for the first time is characterized by typical seizures which are called infantile spasm, finding of hypsarythmia on EEG and psychomotor retardation (23).
It is associated with a variety of emotional and physical symptoms, such as weight loss or gain, insomnia or hypersomnia, psychomotor retardation or agitation, loss of energy and concentration, feelings of worthlessness and hopelessness, and thoughts of suicide or death.
Both have classical clinical features of CDG I, including psychomotor retardation, cerebellar ataxia, strabismus, and cerebellar hypoplasia; the girl also has hypogonadism.
Manifestations of more severe forms of depression include psychotic symptoms (confused delusions or simple hallucinations); social withdrawal; regression (incontinence, deterioration of performance, childish behaviors); and psychomotor retardation.
Children exposed in utero to even low doses of mercury can develop a range of more serious problems--from psychomotor retardation (including delays in speech or walking) to birth defects involving severe brain damage.
In May 2012, a 66-year-old woman was hospitalized in the neurology unit of Bordeaux University Hospital with a 10-day history of fever, asthenia, and psychomotor retardation.
Auditory and visual hallucinations, flat affect, thought-blocking, alogia, suicidal ideation, insomnia, psychomotor retardation, agitation, and anxiety also were noted in the group.